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Failure
of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced
cancer. A controlled trial
Creagan
ET, Moertel CG, O'Fallon JR, Schutt AJ, O'Connell MJ, Rubin J, Frytak S
One
hundred and fifty patients with advanced cancer participated in a controlled
double-blind study to evaluate the effects of high-dose vitamin C on symptoms
and survival.
Patients were divided randomly into a group that received vitamin C (10 g per
day) and one that received a comparably flavored lactose placebo.
Sixty evaluable patients received vitamin C and 63 received a placebo.
Both groups were similar in age, sex, site of primary tumor, performance score,
tumor grade and previous chemotherapy.
The two groups showed no appreciable difference in changes in symptoms,
performance status, appetite or weight.
The median survival for all patients was about seven weeks, and the survival
curves essentially overlapped.
In this selected group of patients, we were unable to show a therapeutic benefit
of high-dose vitamin C treatment.
PMID:
384241 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=384241&dopt=Abstract
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