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Tumoricidal
potential of nutritional manipulations
Demetrakopoulos GE, Brennan MF
Perturbations of specific nutrient availability is the basis of a large number
of chemotherapeutic modalities used in cancer treatment.
The creation of transient nutrient deprivation states by deficient diets
(deficiency), nutrient destruction or displacement (depletion), the presence of
antimetabolites or analogs (deficiency state), or combinations of the above has
shown significant antitumor effect in several animal and human cancers.
Pair-fed isocalonic diets deficient in micronutrients such as carbohydrates
(with or without gluconeogenesis inhibition) or micronutrients such as zinc or
pyridoxine have demonstrated antitumor potential.
Amino acid depletion by enzymes such as L-asparaginase or L-glutaminase has
become a popular modality for treatment of human leukemias.
Purine and pyrimidine analogs or folate antimetabolites have been used
successfully for several decades in the treatment of human tumors.
Excess pyridoxine in tissue culture has demonstrated antineoplastic
potential.
Dietetic supplementation with naturally occurring sugars, sugar derivatives, or
analogs has also demonstrated tumorotropic effects.
PMID: 7055814 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7055814&dopt=Abstract
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