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[Long-term
survival of patients with brain tumors treated with ACNU and PSK after
surgery--with special reference to there immunological follow-up]
[Article
in Japanese]
Saito
Y
Forty-one
non-selected patients with malignant brain tumors have been treated since 1976
with chemoimmunotherapy using ACNU and PSK postoperatively. Eleven (27%) of
these cases have survived usefully over five years, including 6 cases (30%) out
of 20 with glioblastoma (astrocytoma III, IV approximately Kernohan).
This long-term survival response for glioblastoma was considered to be better
than any previous figures in the literature.
Among these 6 cases, one child of 11 years old with brain stem tumor was found
to be so significantly improved by chemoimmunotherapy that no surgery was
needed.
In another patient with astrocytoma III of the bilateral thalamus, the tumor was
seen to be diminished so completely on CT examination after administration of
ACNU(100 mg x 4), that no surgery was needed except for external decompression
and biopsy.
In three other cases local (intracavitary) chemotherapy was performed
successfully.
Local concentration of ACNU in these latter cases 24 h after its insertion was
verified as being markedly higher than that in peripheral blood and brain
tissues after intravascular administration.
In an immunological study of these brain tumors, parameters such as lymphocytes
and T cells in peripheral blood and Ig(G.A.M) in serum were examined.
The results showed that these parameters were almost at normal levels in
long-term survival patients (Group I), low in short-term survivals patients
(Group II died) and normal in all control cases (Group III benign brain tumors,
traumatic disorders etc.).
Combined administration of PSK was considered to be very effective for the
improvement of these parameters.
PMID:
6333212 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6333212&dopt=Abstract
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