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Glycemic
modulation of tumor tolerance in a mouse model of breast cancer
Santisteban GA, Ely JT, Hamel EE, Read DH, Kozawa SM
Marked sensitivity of tumor tolerance to blood glucose level is demonstrated in
a mouse model of human breast cancer.
A theory is cited that explains the high association of hyperglycemia with
malignancy, especially breast cancer, via glycemic modulation of cellular
immunity.
Three groups of BALB/C mice were injected with an aggressive mammary tumor and
placed on three dietary regimens designed to produce three different glycemic
levels.
Mortalities 70 days after injection were 16 of 24 hyperglycemic mice, 8 of 24
normoglycemic, and 1 of 20 hypoglycemic (chi-square p less than .005).
Taken together with other experiments and human data discussed briefly, this
result suggests that glycemic modulation of tumor tolerance should be evaluated
in human trials.
PMID: 4074351 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4074351&dopt=Abstract
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