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Enhancement
of insulin-like growth factor 2 receptors in glioblastoma
Sara VR, Prisell P, Sjogren B, Persson L, Boethius J, Enberg G
The somatomedins (IGF-1/IGF-2) are a family of growth-promoting hormones which
have been identified in the human central nervous system where their specific
receptors are distributed.
The present study identified somatomedin receptors in glioblastoma and compared
them with those found in normal brain.
A significant enhancement in the binding of 125I-IGF-2 but not 125I-IGF-1 to
glioblastoma membranes was found.
A fourfold increase in IGF-2 receptor concentration was observed.
These findings indicate enhanced expression of the IGF-2 receptor in
glioblastoma.
PMID: 2945633 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2945633&dopt=Abstract
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