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Possible
involvement of eicosanoids in the pharmacological action of bromelain
Vellini M, Desideri D, Milanese A, Omini C, Daffonchio
L, Hernandez A, Brunelli G
Bromelain,
a proteolytic enzyme extracted from pineapple plants, was investigated for its
capacity to interfere with arachidonic acid metabolism, since prostaglandins and
other eicosanoids are well-known to be involved in the pathogenesis of
inflammatory diseases.
Bromelain was tested for its ability to interfere with eicosanoids generation in
vivo in two experimentally-induced inflammatory reactions in the rat.
Also antiplatelet aggregation activity of bromelain was studied in ex vivo rat
platelets.
The results seem to indicate an interference of bromelain with arachidonic acid
cascade, which, however, deserves further investigation to be better assessed.
PMID:
3006709 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3006709&dopt=Abstract
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