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Pre-targeted
immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens
Goodwin DA, Meares CF, McCall MJ, McTigue M, Chaovapong W
Nuclear Medicine Service, Veterans Administration Medical Center,
Palo Alto, CA 94304.
A method of tumor imaging utilizing the nonspecific accumulation of antibody
through leaky capillaries is described, in which the antibody and the radiolabel
are administered separately.
Nonradioactive antibody is given first (pre-targeted), and allowed adequate time
to reach maximum tumor concentration.
Depending on the antibody, this may take several days.
At the time of maximum tumor concentration of nonradioactive antibody, the blood
is quickly cleared of excess circulating nonradioactive antibody using a special
i.v. "chase".
The radiolabel then is given and imaging done in 1 to 3 hr.
The use of short lived tracers (hours) to image antibodies that localize slowly
(days) in-vivo is made possible by this method.
PMID: 3346734 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3346734&dopt=Abstract
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