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[Expression
of insulin-like growth factor I receptors in human brain tumors: comparison with
epidermal growth factor receptor by using quantitative autoradiography]
[Article in Japanese]
Kurihara M, Tokunaga Y, Ochi A, Kawaguchi T, Tsutsumi K, Shigematsu K, Niwa
M, Mori K
Department of Neurosurgery, Nagasaki University School of
Medicine, Japan
By using quantitative autoradiographic techniques, receptors for insulin-like
growth factor I (IGF-I) and epidermal growth factor (EGF) were analyzed in 13
samples of human brain tumors (4 low grade astrocytomas, 7 glioblastomas, 1
anaplastic ependymoma and 1 medulloblastoma).
High number of specific binding sites for IGF-I and EGF were homogeneously
present in tissue sections derived from glioblastoma.
In low grade astrocytoma, relatively high numbers of binding site for EGF were
observed, but there was no significant difference in concentrations of IGF-I
binding sites between tumors and control cortex.
In medulloblastoma, only IGF-I binding sites were present.
These observations might indicate that both IGF-I and EGF are involved in the
growth modulation of human gliomas possibly through paracrine or autocrine
mechanisms.
Antagonists to growth factors or monoclonal antibody against those receptors
could have the way for therapeutic application for gliomas.
PMID: 2554948 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2554948&dopt=Abstract
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