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Fuel
utilization in neoplastic disease: implications for the use of nutritional
support in cancer patients
Rothkopf M
Department of Medicine, East Orange Veterans Administration
Medical Center, New Jersey.
Tumor cell metabolism and the whole-body response to tumor metabolic activity
produces a complex derangement, including alterations in carbohydrate oxidation
with futile cycling and changes in gluconeogenesis and lipid utilization.
An interplay between circulating hormones, lymphocyte-mediated cytokines, and
tumor growth factors complicates fuel metabolism in these individuals.
Adequate attention to these concepts has not been provided in the studies
evaluating the effects of parenteral nutrition in cancer patients that have been
performed to date.
Therefore, it is impossible to determine the validity of the results.
Furthermore, it is possible that some of the detrimental effects of TPN observed
in earlier studies were secondary to the inappropriate use of large glucose
loads in cancer patients.
PMID:
2152000 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2152000&dopt=Abstract
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