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PSK (krestin) potentiates
chemotherapeutic effects of tamoxifen on rat mammary carcinomas
Iino
Y, Takai Y, Sugamata N, Morishita Y
Second
Departmen of Surgery, Gunma University School of Medicine, Japan
A
total of 20 mg of 7,12-dimethylbenz[a]anthracene (DMBA) was administered orally
to 41 female Sprague-Dawley (SD) rats (control group), and 60 mg/kg of Krestin
(PSK) were orally administered daily to 38 rats (PSK group) after DMBA
administration.
The average development period (9.6 weeks) of DMBA-induced tumors in the PSK
group was significantly longer (P < 0.02) than that (7.9 weeks) in the
control group.
Average estrogen receptor (ER) levels of established tumors were almost the same
between these two groups.
However, the chemotherapeutic effect of tamoxifen (TAM) was significantly
enhanced by PSK pretreatment.
PMID:
1295453 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1295453&dopt=Abstract
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