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IGF-II
mRNA expression in LI human glioblastoma cell line parallels cell growth
Melino G, Stephanou A, Annicchiarico-Petruzzelli M, Finazzi-Agro A,
Knight RA, Lightman SL
University of
Rome Tor Vergata, Italy
A human glioblastoma cell line was found to express in vitro mRNA transcripts
specific for insulin-like growth factor-II (IGF-II) and growth-hormone
releasing-hormone (GHRH).
In the absence of gross morphological changes, retinoic acid reduced the growth
rate without major change of IGF-II mRNA expression, while
alpha-difluoromethylornithine produced a complete growth arrest and a sharp
decrease of IGF-II mRNA expression.
Both reagents increased the expression of GHRH mRNA.
Also in this glioblastoma cell line, like other neuroectodermal tumours, IGF-II
mRNA is expressed independently from GHRH and seems to be parallel to growth
rate.
PMID: 1436709 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1436709&dopt=Abstract
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