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Intratumoral
gamma-linoleic acid therapy of human gliomas
Naidu
MR, Das UN, Kishan A
Department
of Neurosurgery, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad,
India
In vitro
and in vivo studies have shown that gamma-linoleic acid (GLA), arachidonic acid
(AA) and eicosapentaenoic acid (EPA) can selectively kill tumor cells.
In a clinical trial, the effectiveness of intratumoral administration of GLA in
patients with gliomas was studied.
Of the 6 patients treated, all showed substantial response to GLA as documented
by computerized tomography.
There were no acute side-effects due to the therapy.
This report demonstrates that intratumoral administration of GLA is a possible
approach to the treatment of human glial tumors.
PMID:
1589443 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1589443&dopt=Abstract
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