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Boswellic
acids: novel, specific, nonredox inhibitors of 5-lipoxygenase
Safayhi
H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP
Department
of Pharmacology, University of Tuebingen, FRG
Isomers
(alpha- and beta-) of boswellic acids (BAs), 11-keto-beta-BA and their acetyl
derivatives were isolated from the gum resin of Boswellia serrata.
BA and derivatives concentration dependently decreased the formation of
leukotriene B4 from endogenous arachidonic acid in rat peritoneal neutrophils.
Among the BAs, acetyl-11-keto-beta-BA induced the most pronounced inhibition of
5-lipoxygenase (5-LO) product formation with an IC50 of 1.5 microM.
In contrast to the redox type 5-LO inhibitor nordihydroguaiaretic acid, BA in
concentrations up to 400 microM did not impair the cyclooxygenase and
12-lipoxygenase in isolated human platelets and the peroxidation of arachidonic
acid by Fe-ascorbate.
The data strongly suggest that BAs are specific, nonreducing-type inhibitors of
the 5-LO product formation either interacting directly with the 5-LO or blocking
its translocation.
PMID:
1602379 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1602379&dopt=Abstract
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