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Chlorpromazine
in combination with nitrosourea inhibits experimental glioma growth
Aas
AT, Brun A, Pero RW, Salford LG
Department
of Neurosurgery, Lund University Hospital, Sweden
Modern
cancer therapy has improved the prognosis for several tumour types.
This, however, does not apply to the largest group of brain tumours, the
malignant astrocytomas grades III-IV.
Hence, there is need for new ideas to improve treatment.
Ca2+ and the Ca(2+)-binding protein calmodulin have been shown to be involved in
the processes conferring stability to DNA in proliferating neoplastic cells.
We have combined the calmodulin-inhibiting neuroleptic drug chlorpromazine (CPZ),
with the anti-neoplastic drug 1,3-bis(2-chloroethyl-1)-nitrosourea (BCNU) in a
treatment regime for rats with glioma cells implanted in the brain.
A highly significant inhibiting effect upon the tumour growth was noticed, not
by CPZ or BCNU as single drugs, but with their combination.
PMID:
7917090 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7917090&dopt=Abstract |
