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Suppression
of in vivo tumor-induced angiogenesis by the protein-bound polysaccharide PSK
Kanoh
T, Matsunaga K, Saito K, Fujii T
Kureha
Chemical Ind. Co., Ltd., Biomedical Research Laboratories, Tokyo, Japan
The
anti-angiogenic effects of an antitumor protein-bound polysaccharide, PSK,
obtained from cultured mycelia of Coriolus versicolor in basidiomycetes were
examined by the mouse dorsal air sac assay.
PSK suppressed the mouse hepatoma MH134-induced angiogenesis when assessed by
morphological and biochemical examinations.
This finding suggested that the anti-metastatic effect of PSK is attributed to
the suppression of tumor-induced angiogenesis.
PMID: 7522606 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7522606&dopt=Abstract
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