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Mutant
IGF-I receptors as dominant negatives for growth and transformation
Burgaud JL, Resnicoff M, Baserga R
Jefferson Cancer Center, Thomas Jefferson University,
Philadelphia, PA 19107, USA
The insulin-like growth factor I receptor (IGF-IR) plays a crucial role in cell
growth, transformation and protection from apoptosis.
We have transfected several mutant IGF-IRs into C6 rat glioblastoma cells, in
order to determine whether they can act as dominant negatives.
We find that some of them can act as dominant negatives in growth assays
(monolayer or soft agar), but that none of those examined can induce apoptosis
in C6 cells.
PMID: 7677754 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7677754&dopt=Abstract
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