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Implementing
a ketogenic diet based on medium-chain triglyceride oil in pediatric patients
with cancer
Nebeling LC, Lerner
E
Nutrition Department,
Case Western Reserve University, Cleveland, Ohio 44106-4906, USA
Traditionally, a ketogenic diet is given to drug-resistant children with
epilepsy to improve seizure control.
Inducing a ketogenic state in patients with
cancer may be a useful adjunct to cancer treatment by affecting tumor glucose
metabolism and growth while maintaining the patient's nutritional status.
A
ketogenic diet consisting of 60% medium-chain triglyceride (MCT) oil, 20%
protein, 10% carbohydrate, and 10% other dietary fats was provided to a select
group of pediatric patients with advanced-stage cancer to test the effects of
dietary-induced ketosis on tumor glucose metabolism.
Issues of tolerance and
compliance for patients consuming an oral diet (consisting of normal table foods
and daily MCT oil "shakes") and for patients receiving an enteral
formula are reviewed.
Preliminary use of the MCT oil-based diet suggests a
potential in pediatric patients with cancer.
PMID: 7759747 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7759747&dopt=Abstract
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