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Cognitive
dysfunction following surgery for intracerebral glioma: influence of
histopathology, lesion location, and treatment
Scheibel RS, Meyers CA, Levin VA
Department of Psychiatry, University of California, Los Angeles,
USA
This study examined the relationship between cognitive function, tumor
malignancy, adjunctive therapy, and lesion lateralization following surgery for
intracerebral glioma.
Neuropsychological test battery results showed no difference between patients
with highly malignant gliomas and those with less malignant gliomas, but
differences were found for tumor lateralization and type of therapy.
Scores on a test of graphomotor speed were lowest for patients who had received
radiation or a combination of radiation and chemotherapy, regardless of lesion
location.
Other test results did not differ according to type of prior treatment but were
related instead to tumor lateralization.
Left hemisphere lesions were associated with lower scores on verbal tests, while
right hemisphere lesions were related to lower scores on a test of facial
recognition.
These findings suggest that neuropsychological tests may be useful for
distinguishing between the diffuse side effects of brain tumor therapy and the
focal effects of tumors and surgery on brain functions.
In addition, it appears that any differences in cognitive function due to tumor
malignancy are eliminated or reduced following surgical intervention.
PMID:
8865004 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8865004&dopt=Abstract
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