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Effect
of viscum album in the inhibition of lung metastasis in mice induced by B16F10
melanoma cells
Antony S, Kuttan R, Kuttan
G
Amala Cancer Research Centre, Amala Nagar
Thrissur, Kerala, India
Effect of Iscador, an extract from semiparasitic plant Viscum Album on the
inhibition of lung metastatic colony formation induced by B16F10 melanoma cells
was studied in mice.
Simultaneous administration of drug (1.66 mg/dose) and
B16F10 melanoma cells could inhibit lung nodule formation by 92%. Prophylactic
drug administration produced and inhibition of 78.6% and drug administration
five days after tumour induction produced 68.16% inhibition of lung nodule
formation.
Lung hydroxyproline and serum sialic acid levels were also lower in
the tumour bearing animals treated with Viscum Album. The animals treated with
simultaneous drug administration had an increase of 71.34% in their life span.
PMID: 9261741 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9261741&dopt=Abstract
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