Treatment > Boron Neutron Capture Therapy

Abstract

Boron neutron capture therapy for glioblastoma multiforme using p-boronophenylalanine and epithermal neutrons: trial design and early clinical results

Coderre JA, Elowitz EH, Chadha M, Bergland R, Capala J, Joel DD, Liu HB, Slatkin DN, Chanana AD.

Medical Department Brookhaven National Laboratory, Upton, NY 11973, USA.

A Phase I/II clinical trial of boron neutron capture therapy (BNCT) for glioblastoma multiforme is underway using the amino acid analog p-boronophenylalanine (BPA) and the epithermal neutron beam at the Brook-haven Medical Research Reactor. 
Biodistribution studies were carried out in 18 patients at the time of craniotomy using an i.v. infusion of BPA, solubilized as a fructose complex (BPA-F).
There were no toxic effects related to the BPA-F administration at doses of 130, 170, 210, or 250 mg BPA/kg body weight. 
The tumor/ blood, brain/blood and scalp/blood boron concentration ratios were approximately 3.5:1, 1:1 and 1.5:1, respectively.
Ten patients have received BNCT following 2-hr infusions of 250 mg BPA/kg body weight.
The average boron concentration in the blood during the irradiation was 13.0 +/- 1.5 micrograms 10B/g.
The prescribed maximum dose to normal brain (1 cm3 volume) was 10.5 photon-equivalent Gy (Gy-Eq).
Estimated maximum and minimum doses (mean +/- sd, n = 10) to the tumor volume were 52.6 +/- 4.9 Gy-Eq (range: 64.4-47.6) and 25.2 +/- 4.2 Gy-Eq (range: 32.3-20.0), respectively).
The estimated minimum dose to the target volume (tumor +2 cm margin) was 12.3 +/- 2.7 Gy-Eq (range: 16.2-7.8).
There were no adverse effects on normal brain.
The scalp showed mild erythema, followed by epilation in the 8 cm diameter field.
Four patients developed recurrent tumor, apparently in the lower dose (deeper) regions of the target volume, at post-BNCT intervals of 7,5,3.5 and 3 months, respectively.
The remaining patients have had less than 4 months of post-BNCT follow-up. BNCT, at this starting dose level, appears safe. 
Plans are underway to begin the dose escalation phase of this protocol.

PMID: 9151231 [PubMed - indexed for MEDLINE]