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Neurocutaneous
syndromes: neurofibromatosis 1, neurofibromatosis 2, and tuberous sclerosis
Korf BR
Division of Genetics, Children's Hospital, Harvard Medical
School, Boston, MA 02115, USA.
Neurofibromatosis 1, neurofibromatosis 2, and tuberous sclerosis are a set of
dominantly transmitted disorders that have in common the tendency towards
formation of tumors of the nervous system and other tissues.
The genes for neurofibromatosis 1, neurofibromatosis 2, and one of two forms of
tuberous sclerosis have been identified and appear to act as tumor suppressor
genes.
Information is accumulating about pathogenesis that may eventually improve our
ability to diagnose and treat these disorders.
PMID:
9146993 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9146993&dopt=Abstract
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