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Incidence
of intracranial tumors following hospitalization for head injuries (Denmark)
Peter
D. Inskip1,
Lene Mellemkjaer2,
Gloria Gridley3,
Jørgen
H. Olsen2
1Department
of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A
University College Station, USA; 2,Division
for Cancer Epidemiology, Danish Cancer Society Copenhagen Denmark; 3Epidemiology
and Biostatistics Program, Division of Cancer Epidemiology and Genetics,
National Cancer Institute, National Institutes of Health Bethesda, USA
The
incidence of brain and other intracranial tumors following head trauma was
evaluated in a cohort of 228,055 Danish residents hospitalized because of
concussion, fractured skull, or other head injury between 1977 and 1992 and
followed for an average of eight years (maximum, 17 years).
Traffic accidents, falls, and sports-related incidents were the usual causes of
the injury.
Malignant and benign neoplasms were identified by linking the study roster with
records of the Danish Cancer Registry for the years 1977 to 1993.
This approach precludes differential reporting of injuries by study participants
as an explanation for any associations seen.
Intracranial tumors of the nervous system occurred more often than expected
based on incidence rates for the Danish population; however, most of the excess
occurred during the first year after the injury and likely was due to the
detection of tumors that were present before the injury occurred.
Excluding the first year of follow-up, the standardized incidence ratio (SIR)
was 1.15 (95 percent confidence interval [CI] = 0.99-1.32).
The same general temporal pattern was seen for the major subtypes of brain
tumor as for all types combined.
SIRs after the first year were 1.0 for glioma (CI = 0.8-1.2), 1.2 for meningioma
(CI = 0.8-1.7), and 0.8 for neurilemmoma (CI = 0.4-1.7).
However, hemangioblastoma and hemangioma were more frequent than expected, based
on 15 cases (SIR = 2.6, CI = 1.4-4.2).
Results indicate that head trauma causes, at most, a small increase in the
overall risk of brain tumors
during the ensuing 15 years; however, a possible association with intracranial
vascular tumors warrants further evaluation.
Keywords:
Brain neoplasms, Denmark, glioma, head trauma, hemangioblastoma, meningioma
Copyright
© 1998 Chapman
and Hall. All
rights reserved
Source: http://dx.doi.org/doi:10.1023/A:1008861722901
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