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[The
results of recent research in neurocutaneous syndromes]
[Article in Japanese]
Ohno K
Department of Neurobiology, School of Life Sciences, Tottori
University Faculty of Medicine, Yonago
Identification of NF1, TSC2 and TSC1 genes has enabled us to focus on their
function and regulation.
Evidence suggests that these genes are tumor suppressor genes.
Malignant tissues in NF1 and hamartomatous tissues in TSC show "loss of
heterozygosity" in NF1 and TSC1, 2 genes, respectively.
In addition, in the Eker rat with hereditary renal carcinoma, a mutation in the
TSC2 gene has been identified.
In this review I mentioned briefly several issues to be clarified in the near
future.
PMID:
9545773 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9545773&dopt=Abstract
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