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The expression of insulin-like growth factor I
and insulin-like growth factor II genes in the human fetal and adult brain and
in glioma
Sandberg AC, Engberg C, Lake M, von Holst H, Sara VR
Karolinska Institute's Department of Psychiatry, St. Goran's
Hospital, Stockholm, Sweden
Expression of insulin-like growth factor I (IGF-I) and insulin-like growth
factor II (IGF-II) genes in the human brain and in glioma was studied by slot
blot and Northern analysis following hybridization of IGF-I and IGF-II cDNA
probes to isolated mRNA.
In the fetal brain there were major IGF-I transcripts of 7.5 and 4.4 kilobases
(kb) and one major IGF-II transcript of 6.0 kb.
IGF-II mRNA was less abundant in the adult brain, with IGF-II mRNA being
scarcely detectable.
All glioma tissue examined displayed a marked enhancement of both IGF-I and
IGF-II gene expression when compared to normal brain.
IGF-I transcripts of 4.4 and 2.2-1.8 kb were identified.
Similar to fetal brain a major IGF-II transcript of 6.0 kb was found in the
glioblastoma examined.
PMID: 3211366 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3211366&dopt=Abstract
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