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Nonsteroidal
anti-inflammatory drugs and prevention of colorectal cancer
Arber N,
DuBois RN
Gastrointestinal
Oncology Unit, Department of Gastroenterology, Tel-Aviv Sourasky Medical Center,
6 Weitzmann Street, Tel-Aviv 64-239, Israel
Increasing
evidence suggests that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)
reduce the risk of colorectal cancer.
This observation is supported by results from animal studies that show fewer
tumors per animal and fewer animals with tumors after administration of several
different NSAIDs.
Results from clinical studies with humans consistently support these findings as
well.
The intervention data in familial adenomatous polyposis patients establishes
that the antineoplastic effect may target human adenoma formation.
Supportive evidence comes with both aspirin and non-aspirin NSAIDs.
Earlier detection of lesions as a result of drug-induced gastrointestinal
bleeding does not seem to account for these findings. The molecular mechanism
responsible for the chemopreventive action of this class of drugs is not clear.
Protection may affect several pathways, with results including cell cycle
arrest, induction of apoptosis, and angiogenesis.
This review focuses primarily on the potential chemopreventive activity of
NSAIDS in sporadic human colon cancer and adenomas and outlines current concepts
for the biologic and biochemical mechanisms for this protective effect.
PMID:
10980984 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10980984&dopt=Abstract
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