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The
IGF-I receptor in cancer research
Baserga R
Kimmel Cancer Center, Thomas Jefferson University, 233 S. 10th Street, 624 BLSB,
Philadelphia, Pennsylvania, 19107, USA. r_baserga@lac.jci.tju.edu
The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role
in both normal and abnormal growth.
It is particularly important in
anchorage-independent growth.
Impairment of its function causes apoptosis of
tumor cells and inhibition of tumor growth in experimental animals.
However, the
IGF-IR can also induce differentiation, and eventually cell death, of certain
types of cells.
Its major substrates, IRS-1 and Shc, determine whether the
IGF-IR will transform cells or will cause their differentiation.
Copyright 1999
Academic Press.
PMID: 10579905 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10579905&dopt=Abstract
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