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Increased
survival in brain metastatic patients treated with stereotactic radiotherapy,
omega three fatty acids and bioflavonoids
Gramaglia A, Loi GF, Mongioj V, Baronzio GF
National
Cancer Institute, Milan, Italy.
Stereotactic radiotherapy represents a method to effectively treat brain
metastases with high precision and with high doses.
Few acute toxicities are associated with stereotactic radiotherapy, however
delayed reactions may occur and after six months, 20% of patients can develop
radionecrosis.
To avoid this adverse effect, in patients with metastases localized in critical
brain areas, a supplementation of Omega three fatty acids and bioflavonoids has
been used.
At the end of 1997, we initiated a series of retrospective studies to test the
efficacy of stereotactic radiotherapy on 405 patients, and the prognostic
importance on survival of various variables among which this type of
supplementation.
From the comparison of various survival curves with the Cox multivariate
analysis, it emerged that the patients using this supplementation had a
decreased risk ratio and an improvement in survival time.
A decreased number of radionecrosis was noted.
We suggest their use as radioprotectors.
PMID: 10697622 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10697622&dopt=Abstract
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