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Dietary
supplementation of selenomethionine reduces metastasis of melanoma cells in mice
Yan L, Yee JA, Li D, McGuire MH, Graef GL
Department
of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE
68178, USA. linyan@creighton.edu
The
present study investigated the effect of dietary supplementation of
selenomethionine on pulmonary metastasis of B16BL6 murine melanoma cells in
C57BL/6 mice.
Mice were assigned to four groups of 15 each.
They were fed a
basal AIN93G diet and the basal diet supplemented with 2.5 ppm or 5 ppm selenium
as selenomethionine or with 2.5 ppm selenium as selenite for two weeks before
and after the intravenous injection of 0.5 x 10(5) tumor cells.
At necropsy, the
number and size of tumors that developed in the lungs were determined.
The
number of mice that had > or = 11 tumors was 13, 8, 8, and 6 (p < 0.02
compared with the control), and the median number of lung tumors was 64, 14, 12
(p < 0.05 compared with the control), and 8 (p < 0.01 compared with the
control) in the control group and the groups with 2.5 ppm and 5 ppm selenium as
selenomethionine and 2.5 ppm selenium as selenite. Dietary supplementation of
selenomethionine decreased tumor cross-sectional area and tumor volume compared
with the controls.
At the same dietary level, selenite had a greater inhibitory
effect on tumor size than selenomethionine.
These results demonstrate that
dietary supplementation of selenomethionine reduced experimental metastasis of
melanoma cells in mice and inhibited the growth of metastatic tumors that formed
in the lungs.
It is concluded that selenomethionine is an active form of
selenium that reduces experimental metastasis.
PMID: 10368696 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10368696&dopt=Abstract
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