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Low
serum insulin-like growth factor 1 (IGF-1): a significant association with
prostate cancer
Baffa R, Reiss K, El-Gabry EA, Sedor J, Moy ML, Shupp-Byrne D, Strup SE,
Hauck WW, Baserga R, Gomella LG
Department of Urology, Thomas Jefferson University, Kimmel Cancer
Center, Philadelphia, Pennsylvania 19107, USA.
Purpose. Insulin-like growth factor 1 (IGF-1) is an important mitogenic
and antiapoptotic peptide that affects the proliferation of normal and malignant
cells.
Contradictory reports on the association between serum IGF-1 level and prostate
cancer have been highlighted in the recent literature.
The purpose of this study was to investigate the relation between serum levels
of IGF-1 and prostate cancer.
Materials
and Methods. We
analyzed a population of 57 patients who underwent radical prostatectomy (RP)
for adenocarcinoma.
Serum samples were collected before RP (T0), 6 months after RP (T6), and from 39
age-matched controls.
IGF-1 levels were determined by the active IGF-1 Elisa kit (Diagnostic Systems
Laboratories, Inc.).
Parallel samples were evaluated for prostate-specific antigen (PSA)
levels.
Data between groups were analyzed using Welch's t-test and levels before RP and
after 6 months were compared by paired t-test.
Results.
The normal mean serum IGF-1 for case patients at T0 (124.6+/-58.2 ng/mL) was
significantly lower than the control subjects (157.5+/-70.8 ng/mL; p =
.0192).
The normal mean serum IGF-1 for case patients at T0 (124.91+/-58.6 ng/mL) also
was significantly lower when it was compared with the T6 group (148.49+/-57.2
ng/mL; p = .0056).
No association was found between IGF-1 and PSA blood levels, or IGF-1 and
patient weight (p = 0.2434).
An inverse relation between IGF-1 levels and age in the normal controls (p =
.0041) was observed.
Conclusion.
Findings of this study indicate a significant association between low serum
levels of IGF-1 and prostate cancer.
PMID: 10963500 [PubMed - indexed for MEDLINE]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10963500&dopt=Abstract
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