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Rhodiola
rosea in stress induced fatigue--a double blind cross-over study of a
standardized extract SHR-5 with a repeated low-dose regimen on the mental
performance of healthy physicians during night duty
Darbinyan
V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H
Department
of Neurology, Armenian State Medical University, Yerevan. epilepsy@acc.com
The aim
of this study was to investigate the effect of repeated low-dose treatment with
a standardized extract SHR/5 of rhizome Rhodiola rosea L, (RRE) on fatigue
during night duty among a group of 56 young, healthy physicians.
The effect was measured as total mental performance calculated as Fatigue Index.
The tests chosen reflect an overall level of mental fatigue, involving complex
perceptive and cognitive cerebral functions, such as associative thinking,
short-term memory, calculation and ability of concentration, and speed of
audio-visual perception.
These parameters were tested before and after night duty during three periods of
two weeks each: a) a test period of one RRE/placebo tablet daily, b) a washout
period and c) a third period of one placebo/RRE tablet daily, in a double-blind
cross-over trial.
The perceptive and cognitive cerebral functions mentioned above were
investigated using 5 different tests.
A statistically significant improvement in these tests was observed in the
treatment group (RRE) during the first two weeks period.
No side-effects were reported for either treatment noted.
These results suggest that RRE can reduce general fatigue under certain
stressful conditions.
PMID:
11081987 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11081987&dopt=Abstract
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