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P18
tumor suppressor gene and progression of oligodendrogliomas to
anaplasia
He
J, Hoang-Xuan K, Marie Y, Leuraud P, Mokhtari K, Kujas M, Delattre JY,
Sanson M
INSERM
U495, Hopital de la Salpetriere, Paris, France.
P18INK4C
is a good candidate to be the tumor suppressor gene involved in
oligodendrogliomas on 1p32.
Loss
of heterozygosity on 1p, mutation(s), homozygous deletion(s), and
expression of p18 in 30 oligodendroglial tumors were
investigated.
Loss
of heterozygosity on 1p was found in 15 tumors.
A
p18 mutation was found at a recurrence of an anaplastic
oligodendroglioma, but not in the primary, low-grade tumor.
No
homozygous deletions were found and p18 was expressed in all
cases.
These
results show that p18 alteration is involved in tumor progression in a
subset of oligodendrogliomas.
PMID: 10994011 [PubMed - indexed for MEDLINE]
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