From: Subject: A Mouse Model for Glioma: Biology, Pathology, and Therapeutic Opportunities -- Holland 28 (1): 171 -- Toxicologic Pathology Date: Thu, 17 Apr 2008 16:39:31 +0200 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_002D_01C8A0A9.9C639BF0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 This is a multi-part message in MIME format. ------=_NextPart_000_002D_01C8A0A9.9C639BF0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://tpx.sagepub.com/cgi/content/abstract/28/1/171 A Mouse Model for Glioma: Biology, Pathology, and = Therapeutic Opportunities -- Holland 28 (1): 171 -- Toxicologic = Pathology
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Toxicologic=20 Pathology, Vol. 28, No. 1, 171-177 (2000)
DOI:=20 10.1177/019262330002800122
=A9 2000 Society of = Toxicologic=20 Pathology

A Mouse Model for Glioma: Biology, Pathology, and = Therapeutic=20 Opportunities

Eric C. = Holland=20

M.D. Anderson Cancer Center, Department = of=20 Neurosurgery, Houston, Texas 77030

The epidermal growth factor receptor (EGFR) gene = is=20 amplified or mutated in 30-50% of human = glioblastoma=20 multiforme. These mutations are usually = associated with=20 deletions of the INK43D{alpha}=20-ARF=20 locus, which encodes 2 gene products = (p16INK4a and=20 p19ARF) involved in cell cycle arrest = and=20 apoptosis. We have investigated the role of = EGFR=20 mutation in gliomagenesis using avian retroviral = vectors=20 to transfer a mutant EGFR gene to glial precursors = and=20 astrocytes in transgenic mice. These mice express = tv-a,=20 a gene encoding the retrovirus receptor TVA, = which is=20 under the control of brain cell type-specific = promoters.=20 We demonstrate that expression of a = constitutively=20 active, mutant form of EGFR in cells in the glial = lineage=20 can induce lesions with many similarities to = human=20 gliomas, including increased cell density, vascular=20 proliferation, and immunohistochemical staining for = glial=20 fibrillary acidic protein (GFAP) and nestin. We = also=20 demonstrate that primary astrocytes cultured from = transgenic mice expressing tv-a from the = GFAP=20 promoter are efficiently infected in culture, and such=20 genetically modified cell cultures can be tumorigenic = in=20 nude mice. The combinations of genetic lesions = (eg,=20 mutated EGFR, INK4a-/-) leading to tumor = formation=20 in these 2 mouse systems are similar to those = found in=20 human gliomas. These genetically defined animal = models=20 for gliomas will allow for the testing of = therapies that=20 are targeted specifically at the gene products = involved=20 in the pathogenesis of gliomas.

Key Words: Epidermal growth factor = receptor=20 (EGRF) gene =95 INK4a-ARF =95 gliomagenesis =95 signal = transduction =95 cell=20 cycle arrest

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RIGHT: 0px; = BACKGROUND: url(/icons/collections/universityarea.gif) no-repeat; = PADDING-BOTTOM: 5px; COLOR: #000; PADDING-TOP: 5px; FONT-FAMILY: times; = POSITION: absolute; TOP: auto; TEXT-ALIGN: right; TEXT-DECORATION: none } #universityarea IMG { MARGIN-LEFT: 20px } #tablewrapper { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: = 0px; WIDTH: 100%; PADDING-TOP: 0px } TD#sjobrand { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px; TEXT-ALIGN: left } TD#topbannerad { WIDTH: 42%; TEXT-ALIGN: center } TD#quicksearch { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = VERTICAL-ALIGN: bottom; PADDING-TOP: 5px; WHITE-SPACE: nowrap; = TEXT-ALIGN: right } .find INPUT { VERTICAL-ALIGN: middle; HEIGHT: 22px } .form1 INPUT { FONT-SIZE: 10px; FONT-FAMILY: arial } .form1 SELECT { FONT-SIZE: 10px; FONT-FAMILY: arial } .contentarea .leftcol .find A.formbutton { MARGIN-LEFT: 5px; LINE-HEIGHT: 10px } #navbar { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; PADDING-BOTTOM: 4px; = PADDING-TOP: 4px; TEXT-ALIGN: center } #navbar A { PADDING-RIGHT: 11px; PADDING-LEFT: 11px; FONT-SIZE: 11px; = PADDING-BOTTOM: 4px; COLOR: #fff; PADDING-TOP: 4px; TEXT-DECORATION: = none } #reprint_navbar { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; = PADDING-TOP: 5px; TEXT-ALIGN: center } #reprint_navbar A { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-SIZE: 8px; PADDING-BOTTOM: = 5px; COLOR: #fff; PADDING-TOP: 5px; TEXT-DECORATION: none } #button1 { BACKGROUND-IMAGE: url(/icons/collections/button1.gif) } #button2 { BACKGROUND-IMAGE: url(/icons/collections/button2.gif) } #button3 { BACKGROUND-IMAGE: url(/icons/collections/button3.gif) } #button4 { BACKGROUND-IMAGE: url(/icons/collections/button4.gif) } #button5 { BACKGROUND-IMAGE: url(/icons/collections/button5.gif) } #button6 { BACKGROUND: url(/icons/collections/button6.gif) right top } #subnavbar { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; PADDING-BOTTOM: 0px; COLOR: = #fff; LINE-HEIGHT: 20px; PADDING-TOP: 3px; HEIGHT: 20px; = BACKGROUND-COLOR: #56748e } #subnavbar A { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; FONT-SIZE: 10px; PADDING-BOTTOM: = 4px; COLOR: #fff; PADDING-TOP: 4px; TEXT-DECORATION: none } #subnavbar A.cursor { PADDING-RIGHT: 6px; PADDING-LEFT: 6px; PADDING-BOTTOM: 6px; COLOR: = #fff; PADDING-TOP: 4px; BACKGROUND-COLOR: #9aa19a; TEXT-DECORATION: none } #authenticationstring { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 6px; COLOR: = #000; PADDING-TOP: 6px; BACKGROUND-COLOR: #9aa19a; TEXT-ALIGN: center } #authenticationstring A { COLOR: #02284c } #contentborder { PADDING-RIGHT: 10px; MIN-WIDTH: 750px; PADDING-LEFT: 10px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; BACKGROUND-COLOR: #9aa19a } #maincontent { PADDING-RIGHT: 20px; PADDING-LEFT: 20px; PADDING-BOTTOM: 20px; = PADDING-TOP: 20px; BACKGROUND-COLOR: #fff } #footer { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; FONT-SIZE: 10px; PADDING-BOTTOM: = 4px; PADDING-TOP: 4px; BACKGROUND-COLOR: #9aa19a } #footer A { FONT-SIZE: 10px; COLOR: #02284c } BODY { =09 } BODY.frameleft { BACKGROUND-COLOR: #02284c } .contentarea TABLE TR TD { FONT-SIZE: 75%; FONT-FAMILY: Arial, Helvetica, sans-serif } .contentarea { FONT-SIZE: 75%; FONT-FAMILY: Arial, Helvetica, sans-serif } H2.rubric { BORDER-TOP: #aaa 1px solid; FONT-SIZE: 15px; COLOR: #444; PADDING-TOP: = 2px } H2.rubric .jump { FONT-WEIGHT: bold; FONT-SIZE: 9px; MARGIN-BOTTOM: 0px; PADDING-BOTTOM: = 3px; PADDING-TOP: 2px; TEXT-DECORATION: none } H2.rubric-noborder { FONT-SIZE: 15px; COLOR: #444 } H3 { FONT-WEIGHT: normal; FONT-SIZE: 9px } H3.jrubric { BORDER-TOP: #999 1px solid; FONT-WEIGHT: bold; FONT-SIZE: 9px; = MARGIN-BOTTOM: 0px; PADDING-BOTTOM: 3px; PADDING-TOP: 2px; = TEXT-DECORATION: none } .refine H3 { FONT-WEIGHT: normal; FONT-SIZE: 11px } .refine .right { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 2px = 2px 5px; PADDING-TOP: 0px } .frameleft .contentarea H3.jrubric { FONT-SIZE: 10px } .frameleft { PADDING-RIGHT: 5px; PADDING-LEFT: 20px; PADDING-BOTTOM: 5px; = PADDING-TOP: 0px } .contentarea { PADDING-RIGHT: 15px; PADDING-LEFT: 15px; PADDING-BOTTOM: 15px; = PADDING-TOP: 15px; BACKGROUND-COLOR: #fff } .contentarea TABLE { BORDER-COLLAPSE: collapse } .contentarea TABLE TR TD { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; = VERTICAL-ALIGN: top; PADDING-TOP: 10px } .contentarea .leftcol { PADDING-RIGHT: 20px; WIDTH: 100% } .contentarea .rightcol { WIDTH: 240px } .contentarea .clear { CLEAR: both; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FONT-SIZE: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-TOP: 0px; HEIGHT: 1px } .contentarea .collectionstable { MARGIN-LEFT: 40px } .contentarea .collectionstable TABLE { BORDER-COLLAPSE: collapse } .contentarea .collectionstable TABLE TR TD { PADDING-RIGHT: 10px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; = PADDING-TOP: 0px } .contentarea .collectionstable { =09 } .contentarea .leftcol .form1 INPUT { FONT-SIZE: 10px } .contentarea .leftcol .form1 SELECT { FONT-SIZE: 10px } .contentarea .leftcol .form1 .formbutton { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 9px; PADDING-BOTTOM: 5px; COLOR: #fff; PADDING-TOP: 5px; = BACKGROUND-COLOR: #777; TEXT-DECORATION: none } .contentarea .rightcallout { BORDER-RIGHT: #666 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: #666 1px = solid; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; MARGIN: 4px 0px 4px auto; = BORDER-LEFT: #666 1px solid; WIDTH: 240px; PADDING-TOP: 5px; = BORDER-BOTTOM: #666 1px solid } .contentarea .modify { BACKGROUND-COLOR: #fff } .contentarea .refine { BORDER-RIGHT: #333 1px solid; PADDING-RIGHT: 10px; BORDER-TOP: #333 1px = solid; PADDING-LEFT: 10px; PADDING-BOTTOM: 10px; BORDER-LEFT: #333 1px = solid; PADDING-TOP: 10px; BORDER-BOTTOM: #333 1px solid; = BACKGROUND-COLOR: #dbe1e6 } .contentarea UL.none { LIST-STYLE-TYPE: none } .contentarea LI.none { LIST-STYLE-TYPE: none } .contentarea .leftcol .browsetable { BORDER-RIGHT: #ccc 1px solid; BORDER-TOP: #ccc 1px solid; BORDER-LEFT: = #ccc 1px solid; WIDTH: 510px; BORDER-BOTTOM: #ccc 1px solid; = BACKGROUND-COLOR: #dbe1e6 } .contentarea .leftcol .browsetable TABLE { MARGIN: 10px; BORDER-COLLAPSE: collapse } .contentarea .leftcol .browsetable TD { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } .contentarea .leftcol .browsetable .nav { PADDING-RIGHT: 10px; BORDER-TOP: #666 1px solid; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; PADDING-TOP: 10px } .contentarea .email { MARGIN: 10px; BORDER-COLLAPSE: collapse } .contentarea .email TD { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 3px; = VERTICAL-ALIGN: middle; PADDING-TOP: 3px } .advsearch { FONT-SIZE: 10px; FONT-FAMILY: Arial, Helvetica, sans-serif } .alert STRONG { COLOR: #a70716 } .attention { BORDER-RIGHT: #333 1px solid; PADDING-RIGHT: 5px; BORDER-TOP: #333 1px = solid; PADDING-LEFT: 5px; FONT-SIZE: 10px; PADDING-BOTTOM: 5px; = BORDER-LEFT: #333 1px solid; PADDING-TOP: 5px; BORDER-BOTTOM: #333 1px = solid; BACKGROUND-COLOR: #e6eee4 } .attention P { MARGIN: 0px } .advsearch .right { TEXT-ALIGN: right } .contentarea .modify A.primarynav { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 9px; PADDING-BOTTOM: 5px; COLOR: #fff; PADDING-TOP: 5px; = TEXT-DECORATION: none } .contentarea .rightcol .rightcallout A.primarynav { BACKGROUND-COLOR: #777 } .primarynav { BACKGROUND-COLOR: #777 } .contentarea .modify A.primarynav { BACKGROUND-COLOR: #000 } .disabled { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 9px; BACKGROUND-IMAGE: none; PADDING-BOTTOM: 5px; COLOR: #ccc; = PADDING-TOP: 5px; HEIGHT: 15px; BACKGROUND-COLOR: #777; TEXT-DECORATION: = none } .advsearch .right .search { BACKGROUND-COLOR: #5b0009 } .advsearch .fielded TABLE { BORDER-COLLAPSE: collapse } .advsearch .fielded TABLE TR TD { PADDING-RIGHT: 2px; PADDING-LEFT: 2px; PADDING-BOTTOM: 2px; = VERTICAL-ALIGN: middle; PADDING-TOP: 2px } .advsearch INPUT { FONT-SIZE: 10px; FONT-FAMILY: arial } .advsearch SELECT { FONT-SIZE: 10px; FONT-FAMILY: arial } .primarynav { TEXT-DECORATION: none } .advsearch A.button2 { BORDER-RIGHT: #333 1px solid; PADDING-RIGHT: 8px; BORDER-TOP: #333 1px = solid; PADDING-LEFT: 8px; FONT-SIZE: 9px; PADDING-BOTTOM: 1px; = BORDER-LEFT: #333 1px solid; COLOR: #fff; PADDING-TOP: 1px; = BORDER-BOTTOM: #333 1px solid; BACKGROUND-COLOR: #888; TEXT-DECORATION: = none } .advsearch .add { MARGIN-TOP: 2px; MARGIN-LEFT: 62px } .advsearch .radialcol { =09 } .advsearch .radialcol UL { =09 } .advsearch .radialcol TR TD { BORDER-RIGHT: #ccc 1px solid; PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px = solid; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; BORDER-LEFT: #ccc 1px = solid; PADDING-TOP: 5px; BORDER-BOTTOM: #ccc 1px solid; = BACKGROUND-COLOR: #dbe1e6 } .advsearch .radialcol TD TABLE TR TD { BORDER-RIGHT: medium none; BORDER-TOP: medium none; BORDER-LEFT: medium = none; BORDER-BOTTOM: medium none } .advsearch .radialcol .completelist { OVERFLOW: auto; WIDTH: 400px; HEIGHT: 200px } .advsearch .radialcol { =09 } .advsearch .daterange { =09 } .advsearch .daterange { =09 } .advsearch .daterange { =09 } .advsearch .daterange { =09 } .advsearch .resultformat { =09 } .advsearch .resultformat { =09 } .advsearch .resultformat { =09 } .advsearch .resultformat { =09 } .advanced2 { WIDTH: 600px } .advanced2 .prev { FLOAT: left } .advanced2 .next { FLOAT: right } .hit { FONT-WEIGHT: bold; BACKGROUND: #c1fdb4 } .contentarea .history .item { PADDING-RIGHT: 4px; PADDING-LEFT: 4px; MARGIN-BOTTOM: 1em; = PADDING-BOTTOM: 4px; PADDING-TOP: 4px; BACKGROUND-COLOR: #fff } .contentarea .history .item INPUT { VERTICAL-ALIGN: middle } .contentarea .history .item P { MARGIN: 0.2em } .contentarea .history .item .nav { FONT-SIZE: 90% } .contentarea .history .item { =09 } .contentarea .history .item { =09 } .saveto { VERTICAL-ALIGN: bottom } .saveto INPUT { VERTICAL-ALIGN: bottom } .marked { FONT-SIZE: 1.2em } .marked H1 { FONT-SIZE: 1em } .markeditem { PADDING-RIGHT: 20px; PADDING-LEFT: 20px; MARGIN-BOTTOM: 5px; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; BORDER-BOTTOM: #999 1px solid; = BACKGROUND-COLOR: #fff } .markeditem .itemcopy { =09 } .markeditem .itemcopy H2 { FONT-WEIGHT: normal; FONT-SIZE: 1em; MARGIN: 0px 0px 10px; = TEXT-DECORATION: underline } .markeditem .itemcopy H3 { FONT-WEIGHT: bold; FONT-SIZE: 1em; MARGIN: 0px } .markeditem .itemcopy P { MARGIN: 0px 0px 5px } .markeditem .itemcopy .tools { =09 } .markeditem .itemcopy .tools A { FONT-WEIGHT: bold; VERTICAL-ALIGN: middle } .markeditem .itemcopy .tools INPUT { FONT-WEIGHT: bold; VERTICAL-ALIGN: middle } .markeditem .abstract_off { MARGIN-TOP: 20px; DISPLAY: block } .markeditem .abstract_off H2 { MARGIN: 5px 0px 0px } .markeditem .abstract_off .keywords { FONT-SIZE: 0.9em } .rightcol .rightcallout .abslink { COLOR: #999 } .contentarea .results H1 { FONT-SIZE: 1em } .contentarea .results .cover { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FLOAT: left; PADDING-BOTTOM: = 0px; WIDTH: 75px; PADDING-TOP: 0px } .contentarea .results .cover IMG { MARGIN-BOTTOM: 10px } .contentarea .results .cover .type { BORDER-RIGHT: gray 1px solid; PADDING-RIGHT: 3px; BORDER-TOP: gray 1px = solid; PADDING-LEFT: 3px; PADDING-BOTTOM: 3px; BORDER-LEFT: gray 1px = solid; WIDTH: 50px; PADDING-TOP: 3px; BORDER-BOTTOM: gray 1px solid; = TEXT-ALIGN: center } .contentarea .resultsitem { PADDING-RIGHT: 20px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 5px; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; BORDER-BOTTOM: #999 1px solid; = BACKGROUND-COLOR: #fff } .contentarea .resultsitem .itemcopy { MARGIN-LEFT: 90px } .contentarea .resultsitem .itemcopy H2 { FONT-WEIGHT: normal; FONT-SIZE: 1em; MARGIN: 0px 0px 10px; = TEXT-DECORATION: underline } .contentarea .resultsitem .itemcopy H3 { FONT-WEIGHT: bold; FONT-SIZE: 1em; MARGIN: 0px } .contentarea .resultsitem .itemcopy P { MARGIN: 0px 0px 5px } .contentarea .resultsitem .itemcopy .tools { =09 } .contentarea .resultsitem .itemcopy .tools A { FONT-WEIGHT: bold; VERTICAL-ALIGN: middle } .contentarea .resultsitem .itemcopy .tools INPUT { FONT-WEIGHT: bold; VERTICAL-ALIGN: middle } .contentarea .resultsitem .itemcopy .descriptors { FONT-SIZE: 1.2em; MARGIN: 1em 0px; BORDER-COLLAPSE: collapse } .contentarea .resultsitem .itemcopy .descriptors TD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0.5em; = PADDING-TOP: 0px } .journalhome .leftnav { PADDING-RIGHT: 10px; PADDING-LEFT: 10px; FLOAT: left; PADDING-BOTTOM: = 10px; MARGIN-RIGHT: 20px; PADDING-TOP: 10px; BACKGROUND-COLOR: #fff } .journalhome .leftnav UL.none { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: 0px = 0px 10px; WIDTH: 150px; PADDING-TOP: 0px } .journalhome .issue { FLOAT: left } .journalhome .issue TABLE { BORDER-COLLAPSE: collapse } .journalhome .issue TD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } .journalhome .issue TD H2 { FONT-SIZE: 1.2em; MARGIN: 0px } .journalhome .issue TD P { MARGIN-TOP: 0px } .journalhome .issue TD IMG { MARGIN: 5px 0px } .contentarea .toc .leftcol { PADDING-RIGHT: 10px; DISPLAY: block; PADDING-LEFT: 10px; = PADDING-BOTTOM: 10px; WIDTH: 170px; PADDING-TOP: 10px; BACKGROUND-COLOR: = #ccc } .frameleft { WIDTH: 182px } .frameleft .contentarea FORM { MARGIN: 0px } .frameleft .contentarea P { FONT-SIZE: 10px; MARGIN: 0px } .contentarea .toc .leftcol P { FONT-SIZE: 10px; MARGIN: 0px } H2.jbrand { PADDING-RIGHT: 3px; PADDING-LEFT: 3px; FONT-WEIGHT: normal; FONT-SIZE: = 12px; PADDING-BOTTOM: 3px; MARGIN: 0px; COLOR: white; PADDING-TOP: 3px; = FONT-FAMILY: times; BACKGROUND-COLOR: #1a3a73 } H2.jbrand A { COLOR: white; TEXT-DECORATION: none } .jnav { BORDER-TOP: #999 1px solid } .jnav A { DISPLAY: block; FONT-WEIGHT: bold; MARGIN: 0px; COLOR: #fff; = TEXT-DECORATION: none } .jnavcursor A { DISPLAY: block; FONT-WEIGHT: bold; MARGIN: 0px; COLOR: #fff; = TEXT-DECORATION: none } .jnav A { PADDING-RIGHT: 5px; BORDER-TOP: #999 1px solid; PADDING-LEFT: 5px; = PADDING-BOTTOM: 3px; PADDING-TOP: 3px; BACKGROUND-COLOR: #56748e } H3.jnav { PADDING-RIGHT: 5px; BORDER-TOP: #999 1px solid; PADDING-LEFT: 5px; = PADDING-BOTTOM: 3px; PADDING-TOP: 3px; BACKGROUND-COLOR: #56748e } .jnavcursor A { PADDING-RIGHT: 5px; BORDER-TOP: #999 1px solid; PADDING-LEFT: 5px; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; BACKGROUND-COLOR: #5b0009 } .contentarea .toc .rightcol { WIDTH: auto; BACKGROUND-COLOR: #fff } .contentarea .toc .rightcol FORM { MARGIN: 0px } .contentarea .toc .rightcol .header H1 { DISPLAY: inline } .contentarea .toc .rightcol .header H1 SPAN { FONT-SIZE: 75% } .contentarea .toc .rightcol .header .tools { DISPLAY: inline; MARGIN-LEFT: 5px } .contentarea .toc .rightcol .header .tools P { DISPLAY: inline; MARGIN-LEFT: 5px } .contentarea .toc .rightcol .header .tools SPAN { MARGIN-RIGHT: 15px } .contentarea .toc .rightcol TD.search { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px; BACKGROUND-COLOR: #cecece; TEXT-ALIGN: center } .contentarea .toc .rightcol DL { =09 } .contentarea .toc .rightcol DL DT { =09 } .contentarea .toc .rightcol DL DD { MARGIN-BOTTOM: 10px } .contentarea .toc .rightcol DL DD SPAN { WHITE-SPACE: nowrap } .contentarea .rightcol .modify TABLE { BORDER-COLLAPSE: collapse } .contentarea .rightcol .modify TABLE TD { PADDING-RIGHT: 5px; PADDING-LEFT: 0px; PADDING-BOTTOM: 5px; = PADDING-TOP: 0px } .frameleft .contentarea { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; PADDING-BOTTOM: 5px; WIDTH: = auto; PADDING-TOP: 5px; BACKGROUND-COLOR: #ccc } .frameleft .contentarea P.problems { MARGIN-TOP: 20px; FONT-SIZE: 10px } .contentarea .toc .leftcol { DISPLAY: block; WIDTH: 170px } .contentarea .gray { BACKGROUND-COLOR: #dbe1e6 } .primarynav { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 9px; BACKGROUND-IMAGE: url(/icons/collections/buttonback.gif); = PADDING-BOTTOM: 5px; COLOR: #fff; PADDING-TOP: 5px; HEIGHT: 15px; = BACKGROUND-COLOR: #5b0009; TEXT-DECORATION: none } .primarynavred { PADDING-RIGHT: 5px; PADDING-LEFT: 5px; FONT-WEIGHT: bold; FONT-SIZE: = 9px; BACKGROUND-IMAGE: url(/icons/collections/buttonback.gif); = PADDING-BOTTOM: 5px; COLOR: #fff; PADDING-TOP: 5px; HEIGHT: 15px; = BACKGROUND-COLOR: #5b0009; TEXT-DECORATION: none } .formbutton { BORDER-RIGHT: 0px; PADDING-RIGHT: 3px; BORDER-TOP: 0px; PADDING-LEFT: = 3px; FONT-WEIGHT: bold; FONT-SIZE: 10px; BACKGROUND-IMAGE: = url(/icons/collections/buttonback.gif); PADDING-BOTTOM: 3px; = BORDER-LEFT: 0px; COLOR: #fff; PADDING-TOP: 3px; BORDER-BOTTOM: 0px; = BACKGROUND-COLOR: #5b0009; TEXT-DECORATION: none } .ruled { PADDING-RIGHT: 0px; BORDER-TOP: #999 1px solid; PADDING-LEFT: 0px; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px } .journalarea { BACKGROUND-COLOR: red } .help { BORDER-RIGHT: 0px; PADDING-RIGHT: 0px; BORDER-TOP: 0px; PADDING-LEFT: = 2px; PADDING-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-TOP: 0px; = BORDER-BOTTOM: 0px } #grayedout { COLOR: #9c9c9c } .folderitem { PADDING-RIGHT: 20px; PADDING-LEFT: 20px; MARGIN-BOTTOM: 5px; = PADDING-BOTTOM: 5px; PADDING-TOP: 5px; BORDER-BOTTOM: #999 1px solid; = BACKGROUND-COLOR: #fff } .folderitem H2 { FONT-WEIGHT: normal; FONT-SIZE: 1em; MARGIN: 0px 0px 10px; = TEXT-DECORATION: underline } .folderitem H3 { FONT-WEIGHT: bold; FONT-SIZE: 1em; MARGIN: 0px } .folderitem P { MARGIN: 0px 0px 5px } .folderitem .tools { =09 } .folderitem .tools A { FONT-WEIGHT: bold; VERTICAL-ALIGN: middle } .folderitem .tools INPUT { FONT-WEIGHT: bold; VERTICAL-ALIGN: middle } INPUT.textlink { BORDER-RIGHT: 0px solid; PADDING-RIGHT: 0px; BORDER-TOP: 0px solid; = DISPLAY: inline; PADDING-LEFT: 0px; FONT-SIZE: 12px; BACKGROUND: none = transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; = BORDER-LEFT: 0px solid; CURSOR: pointer; COLOR: #305484; LINE-HEIGHT: = 1em; PADDING-TOP: 0px; BORDER-BOTTOM: 0px solid; FONT-FAMILY: arial; = HEIGHT: 1%; TEXT-ALIGN: left; TEXT-DECORATION: underline } INPUT.textlink2 { BORDER-RIGHT: 0px solid; PADDING-RIGHT: 0px; BORDER-TOP: 0px solid; = PADDING-LEFT: 0px; FONT-WEIGHT: bold; FONT-SIZE: 15px; BACKGROUND: none = transparent scroll repeat 0% 0%; PADDING-BOTTOM: 0px; MARGIN: 0px; = BORDER-LEFT: 0px solid; CURSOR: pointer; COLOR: #305484; LINE-HEIGHT: = 1em; PADDING-TOP: 0px; BORDER-BOTTOM: 0px solid; FONT-FAMILY: arial; = HEIGHT: 1%; TEXT-ALIGN: left; TEXT-DECORATION: underline } .inline_form FORM.form1 { DISPLAY: inline; FONT-SIZE: 10px; FONT-FAMILY: arial } .inline_form INPUT { DISPLAY: inline; FONT-SIZE: 10px; FONT-FAMILY: arial } .inline_form SELECT { DISPLAY: inline; FONT-SIZE: 10px; FONT-FAMILY: arial } DIV.right P { PADDING-RIGHT: 0px; PADDING-LEFT: 125px; PADDING-BOTTOM: 0px; MARGIN: = 0px 0px 5px; PADDING-TOP: 0px } .thislogo IMG { BORDER-RIGHT: medium none; BORDER-TOP: medium none; DISPLAY: block; = BORDER-LEFT: medium none; BORDER-BOTTOM: medium none } #navbarx { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; MARGIN-BOTTOM: 5px; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; TEXT-ALIGN: left } #navbarx A { PADDING-RIGHT: 4px; DISPLAY: inline; PADDING-LEFT: 4px; FONT-SIZE: = 10px; FLOAT: left; PADDING-BOTTOM: 0px; MARGIN: 1px 1px 0px 0px; COLOR: = #fff; LINE-HEIGHT: 18px; PADDING-TOP: 0px; WHITE-SPACE: nowrap; = TEXT-DECORATION: none } A#xbutton1 { BACKGROUND-IMAGE: url(/icons/collections/button1.gif) } A#xbutton2 { BACKGROUND-IMAGE: url(/icons/collections/button2.gif) } A#xbutton3 { BACKGROUND-IMAGE: url(/icons/collections/button3.gif) } A#xbutton4 { BACKGROUND-IMAGE: url(/icons/collections/button4.gif) } A#xbutton5 { BACKGROUND-IMAGE: url(/icons/collections/button5.gif) } A#xbutton6 { PADDING-RIGHT: 8px; BACKGROUND: url(/icons/collections/button6-alt.gif) = no-repeat right top } ------=_NextPart_000_002D_01C8A0A9.9C639BF0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://tpx.sagepub.com/css/ie.css * HTML .visualIEFloatFix { HEIGHT: 0.01% } #navbar { HEIGHT: 1% } #maincontent { HEIGHT: 1% } #mastheadarea { HEIGHT: 1% } #subnavbar { HEIGHT: 1% } #tablewrapper { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 25px 0px 0px; PADDING-TOP: 0px } #subnavbar { HEIGHT: auto } .form1 { =09 } #browseselectform .formbutton { WIDTH: 140px } #browseselectform .formbutton_disabled { WIDTH: 140px } DIV#folders_sidebar { DISPLAY: inline; FLOAT: right; WIDTH: 220px } DIV.folderitem { WIDTH: 450px } ------=_NextPart_000_002D_01C8A0A9.9C639BF0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://tpx.sagepub.com/css/highwire.css #tablewrapper TD { HEIGHT: 50px } .disabled_text { COLOR: #696969 } .formbutton_disabled { BORDER-RIGHT: 0px; PADDING-RIGHT: 3px; BORDER-TOP: 0px; PADDING-LEFT: = 3px; FONT-WEIGHT: bold; FONT-SIZE: 10px; PADDING-BOTTOM: 3px; = BORDER-LEFT: 0px; COLOR: #fff; PADDING-TOP: 3px; BORDER-BOTTOM: 0px; = BACKGROUND-COLOR: #777; TEXT-DECORATION: none } .formbutton_hidden { DISPLAY: none! important } .contentarea .leftcol .browsetable { WIDTH: 600px } .jnlbrowse INPUT { FONT-SIZE: 10px; WIDTH: auto; FONT-FAMILY: arial } .jnlbrowse SELECT { FONT-SIZE: 10px; WIDTH: auto; FONT-FAMILY: arial } .contentarea .rightcallout { WIDTH: 250px } TD#sjobrand IMG { BORDER-RIGHT: medium none; BORDER-TOP: medium none; BORDER-LEFT: medium = none; BORDER-BOTTOM: medium none; TEXT-DECORATION: none } #universityarea IMG { BORDER-RIGHT: medium none; BORDER-TOP: medium none; BORDER-LEFT: medium = none; BORDER-BOTTOM: medium none; TEXT-DECORATION: none } A.no_underline { TEXT-DECORATION: none } A.no_underline:link { TEXT-DECORATION: none } A.no_underline:visited { TEXT-DECORATION: none } A.no_underline:hover { TEXT-DECORATION: none } A.no_underline:active { TEXT-DECORATION: none } #folders_frame { WIDTH: 800px } ------=_NextPart_000_002D_01C8A0A9.9C639BF0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://tpx.sagepub.com/css/content_box.css .contentarea TABLE.content_box_inner_table TR TD { PADDING-RIGHT: 5px; PADDING-LEFT: 8px; PADDING-BOTTOM: 3px; = PADDING-TOP: 3px } TABLE.content_box_outer_table { PADDING-RIGHT: 0px; MARGIN-TOP: -20px; PADDING-LEFT: 0px; = PADDING-BOTTOM: 0px; WIDTH: 25%; PADDING-TOP: 0px } TABLE.content_box_inner_table { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; FONT-FAMILY: Verdana,Arial,Helvetica,sans-serif; = BACKGROUND-COLOR: #f0f0f0 } TD.content_box_title_highlight { FONT-WEIGHT: bold; FONT-SIZE: 120%; VERTICAL-ALIGN: middle; COLOR: = #fff; FONT-STYLE: italic; FONT-FAMILY: "Trebuchet = MS",Verdana,Arial,Helvetica,sans-serif; BACKGROUND-COLOR: #009; = TEXT-ALIGN: center } TD.content_box_title { FONT-WEIGHT: bold; FONT-SIZE: 120%; VERTICAL-ALIGN: middle; COLOR: = #fff; FONT-STYLE: italic; FONT-FAMILY: "Trebuchet = MS",Verdana,Arial,Helvetica,sans-serif; BACKGROUND-COLOR: #009; = TEXT-ALIGN: center } TD.content_box_arrow { TEXT-ALIGN: right } TD.content_box_item { VERTICAL-ALIGN: top; TEXT-ALIGN: left } TD.content_box_item UL { MARGIN-TOP: 3px } TD.content_box_item UL { PADDING-LEFT: 0px; MARGIN-LEFT: 15px } .contentbox_thesaurus_terms LI { FONT-SIZE: 10px } ------=_NextPart_000_002D_01C8A0A9.9C639BF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://tpx.sagepub.com/js/collections.js function MM_findObj(n, d) { //v4.01=0A= var p,i,x; if(!d) d=3Ddocument; = if((p=3Dn.indexOf("?"))>0&&parent.frames.length) {=0A= d=3Dparent.frames[n.substring(p+1)].document; n=3Dn.substring(0,p);}=0A= if(!(x=3Dd[n])&&d.all) x=3Dd.all[n]; for = (i=3D0;!x&&i'+=0A= '' +=0A= ' ' +=0A= '(' +=0A= '' +=0A= ' ' +=0A= '' +=0A= ')' +=0A= '' +=0A= "- = Remove Row" +=0A= ''+=0A= '';=0A= var newdiv =3D document.createElement('div');=0A= newdiv.setAttribute("id",divIdName);=0A= newdiv.innerHTML =3D htmlPreDescriptors + htmlForDescriptors + = htmlPostDescriptors;=0A= ni.appendChild(newdiv);=0A= }=0A= =0A= function removeEvent(divNum) {=0A= var d =3D document.getElementById('myDiv');=0A= var olddiv =3D document.getElementById(divNum);=0A= d.removeChild(olddiv);=0A= }=0A= =0A= // change the ItemIdentifier variable to whatever name you start = radioboxes with=0A= var itemIdentifier =3D 'collection';=0A= var itemIdentifiertwo =3D 'journal';=0A= =0A= function selectSrc(theForm,source, prefix) {=0A= for (i=3D0,n=3DtheForm.elements.length;i'+=0A= '' +=0A= ' ' +=0A= '(' +=0A= '' +=0A= ' ' +=0A= '' +=0A= ')' +=0A= '' +=0A= "- = Remove Row" +=0A= ''+=0A= '';=0A= var newdiv =3D document.createElement('div');=0A= newdiv.setAttribute("id",divIdName);=0A= newdiv.innerHTML =3D htmlPreDescriptors + htmlForDescriptors + = htmlPostDescriptors;=0A= ni.appendChild(newdiv);=0A= }=0A= =0A= function removeSearchRow(divNum) {=0A= var exRowNum =3D parseInt(divNum);=0A= var d =3D document.getElementById('optionalSearchRows');=0A= var olddiv =3D document.getElementById("optionalRow" + divNum);=0A= d.removeChild(olddiv);=0A= var maxRowEl =3D document.getElementById('maxOptionalRowNum');=0A= var maxRowNum =3D parseInt(maxRowEl.value);=0A= for (var i =3D exRowNum; i < maxRowNum; i++) {=0A= var rowToMove =3D i + 1;=0A= var divEl =3D document.getElementById('optionalRow'+rowToMove);=0A= if (divEl !=3D null) {=0A= renumberRowDivElement(divEl, i);=0A= }=0A= }=0A= maxRowEl.value =3D maxRowNum - 1;=0A= }=0A= =0A= function renumberRowDivElement(divEl, moveToNum) {=0A= // moveToNum is the additional (optional) row num-- 1..n=0A= var rowOperatorNum =3D moveToNum + 2;=0A= // update row identifier in select elements=0A= var mySelects =3D divEl.getElementsByTagName("select");=0A= var replaceSelectRegEx =3D new RegExp("([a-z_]+)\\d+","i");=0A= for (var i =3D 0; i < mySelects.length; i++) {=0A= var selectEl =3D mySelects[i];=0A= var origName =3D selectEl.getAttribute("name");=0A= var newName =3D = origName.replace(replaceSelectRegEx,"$1"+rowOperatorNum);=0A= if (newName !=3D origName) {=0A= selectEl.setAttribute("name", newName);=0A= }=0A= }=0A= // update row identifier in input elements=0A= var myInputs =3D divEl.getElementsByTagName("input");=0A= var replaceInputRegEx =3D new RegExp("([a-z_]*term)\\d+([ab])","i");=0A= for (var i =3D 0; i < myInputs.length; i++) {=0A= var inputEl =3D myInputs[i];=0A= var origName =3D inputEl.getAttribute("name");=0A= var newName =3D = origName.replace(replaceInputRegEx,"$1"+rowOperatorNum+"$2");=0A= if (newName !=3D origName) {=0A= inputEl.setAttribute("name", newName);=0A= }=0A= }=0A= // update row identifier in anchor elements=0A= var myAnchors =3D divEl.getElementsByTagName("a");=0A= var replaceAnchorRegEx =3D new = RegExp("removeSearchRow[^\\d]+\\d+.*","i");=0A= for (var i =3D 0; i < myAnchors.length; i++) {=0A= var anchorEl =3D myAnchors[i];=0A= var origOnClick =3D anchorEl.getAttribute("onclick");=0A= if (origOnClick !=3D null) {=0A= var newOnClick =3D origOnClick.replace(replaceAnchorRegEx,=0A= "removeSearchRow(\'"+ moveToNum +"\')");=0A= if (newOnClick !=3D origOnClick) {=0A= anchorEl.setAttribute("onclick", newOnClick);=0A= }=0A= }=0A= }=0A= =0A= // update div name=0A= divEl.setAttribute("id","optionalRow" + moveToNum);=0A= }=0A= =0A= =0A= // ~~~~~~~ Search History ~~~~~~~~~~~~ //=0A= =0A= function history_enableSearch() {=0A= = document.getElementById("searchhistory_search").className=3D"formbutton";=0A= document.getElementById("searchhistory_search").onclick=3Dnull;=0A= }=0A= =0A= function history_disableSearch() {=0A= document.getElementById("searchhistory_search").onclick=3DignoreClick;=0A= = document.getElementById("searchhistory_search").className=3D"formbutton_d= isabled";=0A= }=0A= ------=_NextPart_000_002D_01C8A0A9.9C639BF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://tpx.sagepub.com/javascript/ajax/xmlhttprequest.js /*=0A= =0A= Cross-Browser XMLHttpRequest v1.2=0A= =3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D=3D= =3D=3D=3D=3D=3D=3D=3D=3D=0A= =0A= Emulate Gecko 'XMLHttpRequest()' functionality in IE and Opera. Opera = requires=0A= the Sun Java Runtime Environment .=0A= =0A= by Andrew Gregory=0A= http://www.scss.com.au/family/andrew/webdesign/xmlhttprequest/=0A= =0A= This work is licensed under the Creative Commons Attribution License. To = view a=0A= copy of this license, visit = http://creativecommons.org/licenses/by-sa/2.5/ or=0A= send a letter to Creative Commons, 559 Nathan Abbott Way, Stanford, = California=0A= 94305, USA.=0A= =0A= Attribution: Leave my name and web address in this script intact.=0A= =0A= Not Supported in Opera=0A= ----------------------=0A= * user/password authentication=0A= * responseXML data member=0A= =0A= Not Fully Supported in Opera=0A= ----------------------------=0A= * async requests=0A= * abort()=0A= * getAllResponseHeaders(), getAllResponseHeader(header)=0A= =0A= */=0A= // IE support=0A= if (window.ActiveXObject && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= var msxmls =3D new Array(=0A= 'Msxml2.XMLHTTP.5.0',=0A= 'Msxml2.XMLHTTP.4.0',=0A= 'Msxml2.XMLHTTP.3.0',=0A= 'Msxml2.XMLHTTP',=0A= 'Microsoft.XMLHTTP');=0A= for (var i =3D 0; i < msxmls.length; i++) {=0A= try {=0A= return new ActiveXObject(msxmls[i]);=0A= } catch (e) {=0A= }=0A= }=0A= return null;=0A= };=0A= }=0A= // Gecko support=0A= /* ;-) */=0A= // Opera support=0A= if (window.opera && !window.XMLHttpRequest) {=0A= window.XMLHttpRequest =3D function() {=0A= this.readyState =3D 0; // = 0=3Duninitialized,1=3Dloading,2=3Dloaded,3=3Dinteractive,4=3Dcomplete=0A= this.status =3D 0; // HTTP status codes=0A= this.statusText =3D '';=0A= this._headers =3D [];=0A= this._aborted =3D false;=0A= this._async =3D true;=0A= this._defaultCharset =3D 'ISO-8859-1';=0A= this._getCharset =3D function() {=0A= var charset =3D _defaultCharset;=0A= var contentType =3D = this.getResponseHeader('Content-type').toUpperCase();=0A= val =3D contentType.indexOf('CHARSET=3D');=0A= if (val !=3D -1) {=0A= charset =3D contentType.substring(val);=0A= }=0A= val =3D charset.indexOf(';');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= val =3D charset.indexOf(',');=0A= if (val !=3D -1) {=0A= charset =3D charset.substring(0, val);=0A= }=0A= return charset;=0A= };=0A= this.abort =3D function() {=0A= this._aborted =3D true;=0A= };=0A= this.getAllResponseHeaders =3D function() {=0A= return this.getAllResponseHeader('*');=0A= };=0A= this.getAllResponseHeader =3D function(header) {=0A= var ret =3D '';=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= if (header =3D=3D '*' || this._headers[i].h =3D=3D header) {=0A= ret +=3D this._headers[i].h + ': ' + this._headers[i].v + '\n';=0A= }=0A= }=0A= return ret;=0A= };=0A= this.getResponseHeader =3D function(header) {=0A= var ret =3D getAllResponseHeader(header);=0A= var i =3D ret.indexOf('\n');=0A= if (i !=3D -1) {=0A= ret =3D ret.substring(0, i);=0A= }=0A= return ret;=0A= };=0A= this.setRequestHeader =3D function(header, value) {=0A= this._headers[this._headers.length] =3D {h:header, v:value};=0A= };=0A= this.open =3D function(method, url, async, user, password) {=0A= this.method =3D method;=0A= this.url =3D url;=0A= this._async =3D true;=0A= this._aborted =3D false;=0A= this._headers =3D [];=0A= if (arguments.length >=3D 3) {=0A= this._async =3D async;=0A= }=0A= if (arguments.length > 3) {=0A= opera.postError('XMLHttpRequest.open() - user/password not = supported');=0A= }=0A= this.readyState =3D 1;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= };=0A= this.send =3D function(data) {=0A= if (!navigator.javaEnabled()) {=0A= alert("XMLHttpRequest.send() - Java must be installed and = enabled.");=0A= return;=0A= }=0A= if (this._async) {=0A= setTimeout(this._sendasync, 0, this, data);=0A= // this is not really asynchronous and won't execute until the = current=0A= // execution context ends=0A= } else {=0A= this._sendsync(data);=0A= }=0A= }=0A= this._sendasync =3D function(req, data) {=0A= if (!req._aborted) {=0A= req._sendsync(data);=0A= }=0A= };=0A= this._sendsync =3D function(data) {=0A= this.readyState =3D 2;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= // open connection=0A= var url =3D new java.net.URL(new = java.net.URL(window.location.href), this.url);=0A= var conn =3D url.openConnection();=0A= for (var i =3D 0; i < this._headers.length; i++) {=0A= conn.setRequestProperty(this._headers[i].h, this._headers[i].v);=0A= }=0A= this._headers =3D [];=0A= if (this.method =3D=3D 'POST') {=0A= // POST data=0A= conn.setDoOutput(true);=0A= var wr =3D new = java.io.OutputStreamWriter(conn.getOutputStream(), this._getCharset());=0A= wr.write(data);=0A= wr.flush();=0A= wr.close();=0A= }=0A= // read response headers=0A= // NOTE: the getHeaderField() methods always return nulls for me :(=0A= var gotContentEncoding =3D false;=0A= var gotContentLength =3D false;=0A= var gotContentType =3D false;=0A= var gotDate =3D false;=0A= var gotExpiration =3D false;=0A= var gotLastModified =3D false;=0A= for (var i =3D 0; ; i++) {=0A= var hdrName =3D conn.getHeaderFieldKey(i);=0A= var hdrValue =3D conn.getHeaderField(i);=0A= if (hdrName =3D=3D null && hdrValue =3D=3D null) {=0A= break;=0A= }=0A= if (hdrName !=3D null) {=0A= this._headers[this._headers.length] =3D {h:hdrName, = v:hdrValue};=0A= switch (hdrName.toLowerCase()) {=0A= case 'content-encoding': gotContentEncoding =3D true; break;=0A= case 'content-length' : gotContentLength =3D true; break;=0A= case 'content-type' : gotContentType =3D true; break;=0A= case 'date' : gotDate =3D true; break;=0A= case 'expires' : gotExpiration =3D true; break;=0A= case 'last-modified' : gotLastModified =3D true; break;=0A= }=0A= }=0A= }=0A= // try to fill in any missing header information=0A= var val;=0A= val =3D conn.getContentEncoding();=0A= if (val !=3D null && !gotContentEncoding) = this._headers[this._headers.length] =3D {h:'Content-encoding', v:val};=0A= val =3D conn.getContentLength();=0A= if (val !=3D -1 && !gotContentLength) = this._headers[this._headers.length] =3D {h:'Content-length', v:val};=0A= val =3D conn.getContentType();=0A= if (val !=3D null && !gotContentType) = this._headers[this._headers.length] =3D {h:'Content-type', v:val};=0A= val =3D conn.getDate();=0A= if (val !=3D 0 && !gotDate) this._headers[this._headers.length] = =3D {h:'Date', v:(new Date(val)).toUTCString()};=0A= val =3D conn.getExpiration();=0A= if (val !=3D 0 && !gotExpiration) = this._headers[this._headers.length] =3D {h:'Expires', v:(new = Date(val)).toUTCString()};=0A= val =3D conn.getLastModified();=0A= if (val !=3D 0 && !gotLastModified) = this._headers[this._headers.length] =3D {h:'Last-modified', v:(new = Date(val)).toUTCString()};=0A= // read response data=0A= var reqdata =3D '';=0A= var stream =3D conn.getInputStream();=0A= if (stream) {=0A= var reader =3D new java.io.BufferedReader(new = java.io.InputStreamReader(stream, this._getCharset()));=0A= var line;=0A= while ((line =3D reader.readLine()) !=3D null) {=0A= if (this.readyState =3D=3D 2) {=0A= this.readyState =3D 3;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= }=0A= reqdata +=3D line + '\n';=0A= }=0A= reader.close();=0A= this.status =3D 200;=0A= this.statusText =3D 'OK';=0A= this.responseText =3D reqdata;=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onload) {=0A= this.onload();=0A= }=0A= } else {=0A= // error=0A= this.status =3D 404;=0A= this.statusText =3D 'Not Found';=0A= this.responseText =3D '';=0A= this.readyState =3D 4;=0A= if (this.onreadystatechange) {=0A= this.onreadystatechange();=0A= }=0A= if (this.onerror) {=0A= this.onerror();=0A= }=0A= }=0A= };=0A= };=0A= }=0A= // ActiveXObject emulation=0A= if (!window.ActiveXObject && window.XMLHttpRequest) {=0A= window.ActiveXObject =3D function(type) {=0A= switch (type.toLowerCase()) {=0A= case 'microsoft.xmlhttp':=0A= case 'msxml2.xmlhttp':=0A= case 'msxml2.xmlhttp.3.0':=0A= case 'msxml2.xmlhttp.4.0':=0A= case 'msxml2.xmlhttp.5.0':=0A= return new XMLHttpRequest();=0A= }=0A= return null;=0A= };=0A= }=0A= ------=_NextPart_000_002D_01C8A0A9.9C639BF0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://tpx.sagepub.com/javascript/ajax/utility.js /************************************************************************= *****=0A= * javascript/ajax/utility.js=0A= *=0A= * Utility functions for working with XMLHttpRequest data.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Copy XML nodes into an HTMLElement. This effectively=0A= * clones XML markup which uses XHTML naming conventions=0A= * into an HTML DOM.=0A= */=0A= function copy_xml_to_html(src, dst) {=0A= if (src.nodeType =3D=3D 1) { /* Node.ELEMENT_NODE */=0A= var e =3D document.createElement(src.nodeName);=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], e);=0A= }=0A= for (var i =3D 0; i < src.attributes.length; i++) {=0A= var n =3D src.attributes[i].name;=0A= var v =3D unescape_xml_string(src.attributes[i].value); =0A= e.setAttribute(n, v);=0A= if (n =3D=3D "class") {=0A= e.className =3D v;=0A= }=0A= else if (n =3D=3D "style") {=0A= set_css_style(v, e, "");=0A= }=0A= }=0A= dst.appendChild(e);=0A= }=0A= else if (src.nodeType =3D=3D 3) { /* Node.TEXT_NODE */=0A= dst.appendChild(document.createTextNode(src.nodeValue));=0A= }=0A= }=0A= =0A= /* =0A= * It is unclear that this is the right thing to be calling=0A= * from copy_xml_to_html, but it appears that Safari decides=0A= * to convert & to the NCR #, and then encodes that=0A= * NCR to &%26%2338;. So, I'm going to treat the DOM Attr=0A= * value as a plain string, and run our XML string input=0A= * through the decoding routine below.=0A= */=0A= function unescape_xml_string(s) {=0A= return s.replace(/'/g, "'")=0A= .replace(/'/g, "'")=0A= .replace(/"/g, "\"")=0A= .replace(/"/g, "\"")=0A= .replace(/>/g, ">")=0A= .replace(/>/g, ">")=0A= .replace(/</g, "<")=0A= .replace(/</g, "<")=0A= .replace(/&/g, "&")=0A= .replace(/&/g, "&");=0A= }=0A= =0A= /*=0A= * Parse set of CSS rules and apply them to an element.=0A= * This is quite horrifying, but I'm unable to determine=0A= * how else to handle this with IE 6. FireFox and other=0A= * sane browsers let you simply set the style attribute=0A= * or use e.style.setProperty(rule, value, priority),=0A= * IE 6 appears to have neither of these capabilities..=0A= */=0A= function set_css_style(css, e, priority) {=0A= var rules =3D css.split(";");=0A= for (var i =3D 0; i < rules.length; i++) {=0A= var nvpair =3D rules[i].split(":");=0A= if (nvpair.length =3D=3D 2) {=0A= try {=0A= var name =3D nvpair[0]; /* style attribute */=0A= var value =3D nvpair[1]; /* attribute value */=0A= =0A= /*=0A= * For each possible style attribute, set the=0A= * appropriate style property in the element.=0A= */=0A= if (name =3D=3D "background") {=0A= e.style.background =3D value;=0A= }=0A= else if (name =3D=3D "background-attachment") {=0A= e.style.backgroundAttachment =3D value;=0A= }=0A= else if (name =3D=3D "background-color") {=0A= e.style.backgroundColor =3D value;=0A= }=0A= else if (name =3D=3D "background-image") {=0A= e.style.backgroundImage =3D value;=0A= }=0A= else if (name =3D=3D "background-position") {=0A= e.style.backgroundPosition =3D value;=0A= }=0A= else if (name =3D=3D "background-position-x") {=0A= e.style.backgroundPositionX =3D value;=0A= }=0A= else if (name =3D=3D "background-position-y") {=0A= e.style.backgroundPositionY =3D value;=0A= }=0A= else if (name =3D=3D "background-repeat") {=0A= e.style.backgroundRepeat =3D value;=0A= }=0A= else if (name =3D=3D "behavior") {=0A= e.style.behavior =3D value;=0A= }=0A= else if (name =3D=3D "border") {=0A= e.style.border =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom") {=0A= e.style.borderBottom =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-color") {=0A= e.style.borderBottomColor =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-style") {=0A= e.style.borderBottomStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-bottom-width") {=0A= e.style.borderBottomWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-collapse") {=0A= e.style.borderCollapse =3D value;=0A= }=0A= else if (name =3D=3D "border-color") {=0A= e.style.borderColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left") {=0A= e.style.borderLeft =3D value;=0A= }=0A= else if (name =3D=3D "border-left-color") {=0A= e.style.borderLeftColor =3D value;=0A= }=0A= else if (name =3D=3D "border-left-style") {=0A= e.style.borderLeftStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-left-width") {=0A= e.style.borderLeftWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-right") {=0A= e.style.borderRight =3D value;=0A= }=0A= else if (name =3D=3D "border-right-color") {=0A= e.style.borderRightColor =3D value;=0A= }=0A= else if (name =3D=3D "border-right-style") {=0A= e.style.borderRightStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-right-width") {=0A= e.style.borderRightWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-style") {=0A= e.style.borderStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top") {=0A= e.style.borderTop =3D value;=0A= }=0A= else if (name =3D=3D "border-top-color") {=0A= e.style.borderTopColor =3D value;=0A= }=0A= else if (name =3D=3D "border-top-style") {=0A= e.style.borderTopStyle =3D value;=0A= }=0A= else if (name =3D=3D "border-top-width") {=0A= e.style.borderTopWidth =3D value;=0A= }=0A= else if (name =3D=3D "border-width") {=0A= e.style.borderWidth =3D value;=0A= }=0A= else if (name =3D=3D "bottom") {=0A= e.style.bottom =3D value;=0A= }=0A= else if (name =3D=3D "clear") {=0A= e.style.clear =3D value;=0A= }=0A= else if (name =3D=3D "clip") {=0A= e.style.clip =3D value;=0A= }=0A= else if (name =3D=3D "color") {=0A= e.style.color =3D value;=0A= }=0A= else if (name =3D=3D "cssText") {=0A= e.style.Sets =3D value;=0A= }=0A= else if (name =3D=3D "cursor") {=0A= e.style.cursor =3D value;=0A= }=0A= else if (name =3D=3D "direction") {=0A= e.style.direction =3D value;=0A= }=0A= else if (name =3D=3D "display") {=0A= e.style.display =3D value;=0A= }=0A= else if (name =3D=3D "font") {=0A= e.style.font =3D value;=0A= }=0A= else if (name =3D=3D "font-family") {=0A= e.style.fontFamily =3D value;=0A= }=0A= else if (name =3D=3D "font-size") {=0A= e.style.fontSize =3D value;=0A= }=0A= else if (name =3D=3D "font-style") {=0A= e.style.fontStyle =3D value;=0A= }=0A= else if (name =3D=3D "font-variant") {=0A= e.style.fontVariant =3D value;=0A= }=0A= else if (name =3D=3D "font-weight") {=0A= e.style.fontWeight =3D value;=0A= }=0A= else if (name =3D=3D "height") {=0A= e.style.height =3D value;=0A= }=0A= else if (name =3D=3D "ime-mode") {=0A= e.style.imeMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-flow") {=0A= e.style.layoutFlow =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid") {=0A= e.style.layoutGrid =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-char") {=0A= e.style.layoutGridChar =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-line") {=0A= e.style.layoutGridLine =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-mode") {=0A= e.style.layoutGridMode =3D value;=0A= }=0A= else if (name =3D=3D "layout-grid-type") {=0A= e.style.layoutGridType =3D value;=0A= }=0A= else if (name =3D=3D "left") {=0A= e.style.left =3D value;=0A= }=0A= else if (name =3D=3D "letter-spacing") {=0A= e.style.letterSpacing =3D value;=0A= }=0A= else if (name =3D=3D "line-break") {=0A= e.style.lineBreak =3D value;=0A= }=0A= else if (name =3D=3D "line-height") {=0A= e.style.lineHeight =3D value;=0A= }=0A= else if (name =3D=3D "list-style") {=0A= e.style.listStyle =3D value;=0A= }=0A= else if (name =3D=3D "list-style-image") {=0A= e.style.listStyleImage =3D value;=0A= }=0A= else if (name =3D=3D "list-style-position") {=0A= e.style.listStylePosition =3D value;=0A= }=0A= else if (name =3D=3D "list-style-type") {=0A= e.style.listStyleType =3D value;=0A= }=0A= else if (name =3D=3D "margin") {=0A= e.style.margin =3D value;=0A= }=0A= else if (name =3D=3D "margin-bottom") {=0A= e.style.marginBottom =3D value;=0A= }=0A= else if (name =3D=3D "margin-left") {=0A= e.style.marginLeft =3D value;=0A= }=0A= else if (name =3D=3D "margin-right") {=0A= e.style.marginRight =3D value;=0A= }=0A= else if (name =3D=3D "margin-top") {=0A= e.style.marginTop =3D value;=0A= }=0A= else if (name =3D=3D "min-height") {=0A= e.style.minHeight =3D value;=0A= }=0A= else if (name =3D=3D "overflow") {=0A= e.style.overflow =3D value;=0A= }=0A= else if (name =3D=3D "overflow-x") {=0A= e.style.overflowX =3D value;=0A= }=0A= else if (name =3D=3D "overflow-y") {=0A= e.style.overflowY =3D value;=0A= }=0A= else if (name =3D=3D "padding") {=0A= e.style.padding =3D value;=0A= }=0A= else if (name =3D=3D "padding-bottom") {=0A= e.style.paddingBottom =3D value;=0A= }=0A= else if (name =3D=3D "padding-left") {=0A= e.style.paddingLeft =3D value;=0A= }=0A= else if (name =3D=3D "padding-right") {=0A= e.style.paddingRight =3D value;=0A= }=0A= else if (name =3D=3D "padding-top") {=0A= e.style.paddingTop =3D value;=0A= }=0A= else if (name =3D=3D "page-break-after") {=0A= e.style.pageBreakAfter =3D value;=0A= }=0A= else if (name =3D=3D "page-break-before") {=0A= e.style.pageBreakBefore =3D value;=0A= }=0A= else if (name =3D=3D "pixelBottom") {=0A= e.style.pixelBottom =3D value;=0A= }=0A= else if (name =3D=3D "pixelHeight") {=0A= e.style.pixelHeight =3D value;=0A= }=0A= else if (name =3D=3D "pixelLeft") {=0A= e.style.pixelLeft =3D value;=0A= }=0A= else if (name =3D=3D "pixelRight") {=0A= e.style.pixelRight =3D value;=0A= }=0A= else if (name =3D=3D "pixelTop") {=0A= e.style.pixelTop =3D value;=0A= }=0A= else if (name =3D=3D "pixelWidth") {=0A= e.style.pixelWidth =3D value;=0A= }=0A= else if (name =3D=3D "posBottom") {=0A= e.style.posBottom =3D value;=0A= }=0A= else if (name =3D=3D "posHeight") {=0A= e.style.posHeight =3D value;=0A= }=0A= else if (name =3D=3D "position") {=0A= e.style.position =3D value;=0A= }=0A= else if (name =3D=3D "posLeft") {=0A= e.style.posLeft =3D value;=0A= }=0A= else if (name =3D=3D "posRight") {=0A= e.style.posRight =3D value;=0A= }=0A= else if (name =3D=3D "posTop") {=0A= e.style.posTop =3D value;=0A= }=0A= else if (name =3D=3D "posWidth") {=0A= e.style.posWidth =3D value;=0A= }=0A= else if (name =3D=3D "right") {=0A= e.style.right =3D value;=0A= }=0A= else if (name =3D=3D "ruby-align") {=0A= e.style.rubyAlign =3D value;=0A= }=0A= else if (name =3D=3D "ruby-overhang") {=0A= e.style.rubyOverhang =3D value;=0A= }=0A= else if (name =3D=3D "ruby-position") {=0A= e.style.rubyPosition =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-3dlight-color") {=0A= e.style.scrollbar3dLightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-arrow-color") {=0A= e.style.scrollbarArrowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-base-color") {=0A= e.style.scrollbarBaseColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-darkshadow-color") {=0A= e.style.scrollbarDarkShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-face-color") {=0A= e.style.scrollbarFaceColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-highlight-color") {=0A= e.style.scrollbarHighlightColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-shadow-color") {=0A= e.style.scrollbarShadowColor =3D value;=0A= }=0A= else if (name =3D=3D "scrollbar-track-color") {=0A= e.style.scrollbarTrackColor =3D value;=0A= }=0A= else if (name =3D=3D "float") {=0A= e.style.styleFloat =3D value;=0A= }=0A= else if (name =3D=3D "table-layout") {=0A= e.style.tableLayout =3D value;=0A= }=0A= else if (name =3D=3D "text-align") {=0A= e.style.textAlign =3D value;=0A= }=0A= else if (name =3D=3D "text-align-last") {=0A= e.style.textAlignLast =3D value;=0A= }=0A= else if (name =3D=3D "text-autospace") {=0A= e.style.textAutospace =3D value;=0A= }=0A= else if (name =3D=3D "text-decoration") {=0A= e.style.textDecoration =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationBlink") {=0A= e.style.textDecorationBlink =3D value;=0A= }=0A= else if (name =3D=3D "textDecorationLineThrough") {=0A= e.style.textDecorationLineThrough =3D value;=0A= }=0A= else if (name =3D=3D 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quoted-printable Content-Location: http://tpx.sagepub.com/javascript/entrez/callback.js /************************************************************************= *****=0A= * javascript/entrez/callback.js=0A= *=0A= * Entrez Linking callback to populate content box.=0A= *=0A= * Copyright 2006 Board of Trustees of the Leland Stanford Junior = University.=0A= = *************************************************************************= ***/=0A= =0A= /*=0A= * Execute callback to fill content box with Entrez Linking information.=0A= */=0A= function entrez_callback(pmid, callback_url) {=0A= /*=0A= * MSIE 5.5 and below have issues with the JavaScript=0A= * used for Entrez Linking. For now we have to disable=0A= * the callback until we can track down a proper fix=0A= * (or everybody sanely upgrades to version 6 or 7!).=0A= */=0A= if (navigator) {=0A= var appname =3D navigator.appName;=0A= if (appname =3D=3D "Microsoft Internet Explorer") {=0A= var userAgent =3D navigator["userAgent"];=0A= var s =3D "MSIE ";=0A= var n =3D -1; =0A= if ((n =3D userAgent.indexOf(s)) !=3D -1) {=0A= var v =3D parseFloat(userAgent.substring(n+s.length));=0A= if (v < 6) {=0A= return;=0A= }=0A= }=0A= }=0A= }=0A= =0A= /*=0A= * Acquire table row element to update, initiate callback=0A= * to update table with Entrez Links.=0A= */=0A= var tr =3D document.getElementById('entrez_callback_'+pmid);=0A= if (!tr) {=0A= return;=0A= }=0A= var req =3D new XMLHttpRequest();=0A= if (!req) {=0A= return;=0A= }=0A= req.onreadystatechange =3D function() {=0A= if (req.readyState =3D=3D 4 && (req.status =3D=3D 200 || req.status = =3D=3D 304)) {=0A= var src =3D req.responseXML.documentElement;=0A= var dst =3D document.createDocumentFragment();=0A= for (var i =3D 0; i < src.childNodes.length; i++) {=0A= copy_xml_to_html(src.childNodes[i], dst);=0A= }=0A= var tbl =3D tr.parentNode;=0A= tbl.replaceChild(dst, tr);=0A= }=0A= }=0A= req.open('GET', callback_url, true);=0A= req.send(null);=0A= }=0A= ------=_NextPart_000_002D_01C8A0A9.9C639BF0--