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Concentration-dependent
potentiating and inhibitory effects of Boswellia extracts on 5-lipoxygenase
product formation in stimulated PMNL
Safayhi H,
Boden SE, Schweizer S, Ammon HP
Department
of Pharmacology, University of Tuebingen, Germany.
hasan.safayhi@uni-tuebingen.de
Preparations
from the gum of Boswellia spec. have been used in the traditional medicine for
the treatment of inflammatory diseases.
Extracts from B. serrata gum were shown to inhibit leukotriene biosynthesis by
impairing the 5-lipoxygenase (5-LO) activity.
In order to identify the minimal effective concentrations of extracts in vitro
we studied the effects of ethanolic extracts from commercially available resins
from two regions (B. serrata gum from India and Olibanum in granis from Arabia)
on the 5-LO product formation from endogenous substrate in calcium and ionophore
stimulated neutrophils in a defined concentration range.
Both extracts inhibited 5-LO product formation in vitro in concentrations
greater than 10 to 15 micrograms/ml as reported previously for an ethanolic B.
serrata extract.
In contrast, lower concentrations of extracts (1 to 10 micrograms/ml) even
potentiated 5-LO product formation, especially the biosynthesis of 5(S)-HETE.
The in vitro data underline the major importance of drug standardization when
Boswellia resin containing preparations are used for the treatment of diseases.
PMID: 10763581 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10763581&dopt=Abstract
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