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Molecular
events implicated in brain tumor angiogenesis and invasion
Zagzag D, Friedlander DR, Margolis B, Grumet M, Semenza GL,
Zhong H, Simons JW, Holash J, Wiegand SJ, Yancopoulos GD
Division of Neuropathology, Department of Pathology, New York
University School of Medicine, New York, NY 10016, USA.
We have conducted studies designed to help elucidate the molecular
mechanisms involved in brain tumor invasion and angiogenesis,
which are critical in the growth of malignant tumors of the
central nervous system.
A variety of molecular factors have been implicated in these
processes.
Here we focus on three that are of particular importance in the
progression of brain tumors.
Angiopoietins are involved in the regulation of vascular
development.
Hypoxia inducible factor-1 is a transcription factor that
up-regulates genes, including genes encoding vascular endothelial
growth factor under hypoxic conditions.
Focal adhesion kinase is associated with infiltration of tumor
cells and angiogenesis.
Copyright
2000 S. Karger AG, Basel.
PMID:
11025423 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11025423
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