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Adult
brain low-grade astrocytomas: survival after surgery and radiotherapy
Arienti VM, Botturi A, Boiardi A, Broggi G, Collice M,
Fariselli L, Zanni D, Botturi M
Niguarda Ca' Granda General Hospital, Piazza Ospedale Maggiore 3,
I-20162 Milan, Italy
In order to
identify prognostic factors of survival, twelve elements of disease
and treatment have been evaluated for a population of 49 patients with
diffuse low-grade astrocytoma treated with surgical resection and
radiotherapy.
The survival values were inversely correlated with age
and major residual portion.
On the other hand, KPS, lobar site, grade
II Daumas-Duport lesions, protoplasmatic variant, early epilepsy,
hyperfractionated radiotherapy and extent of exeresis were prognostic
factors correlated with survival.
Tumor extent and radiation total
dose were not correlated in a meaningful way.
Only KPS was
statistically significant when compared to all the prognostic factors.
We believe that patient selection according to age, lesion site and
histological features are not sufficient to generate a homogeneous
tumoral population.
The most appropriate therapy for treating
low-grade astrocytomas is still an open subject.
However, recent
studies have shown that the prognostic value of a group of factors is
useful to plan controlled studies that compare differentiated
treatment protocols.
PMID: 11731876 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11731876&dopt=Abstract
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