|
Shc
signalling in neural stem cells
Cattaneo
E
University
of Milan, Italy
Improving
the generation of neuronal cells from neural stem cells (NSC) and their capacity
to integrate once grafted in the host brain, represent one of the major
challenge for cell replacement and gene therapy approaches to the brain.
For this to be achieved a deeper understanding of the biology of NSC becomes
necessary.
A large number of studies have demonstrated that NSC division and
differentiation can be controlled by extrinsic stimuli.
One of the most important signalling pathways is from receptor protein tyrosine
kinases, via Shc(s) and Grb2 adaptor proteins, which leads to stimulation of the
Ras-MAPK and other pathways.
Little is known about the contribution of this signalling proteins at the
transition from proliferation to differentiation in the brain.
Our work is focussed on the role of SHC (Src Homologue and Collagene homologue)
adaptor proteins.
We demonstrated that at the transition from proliferation to neuronal
differentiation in the brain, important changes occur in the availability of
specific members of the Shc family.
We propose that changes in these connector/adaptor molecules will ultimately
determine whether the growth factors will push the system towards either
division or neuronal differentiation.
A strategy can be anticipated to improve neurons generation from NSC by
manipulation of SHC molecules.
Source: http://www.tumoricerebrali.it/public/congressi/parma2001/speakers.pdf
|
