Epidemiology and Risk Factors | Etiology and Pathogenesis > Familiality


Cancer Causes and Control, 12 (3): 195-199, April 2001 (Epidemiology Report)


Abstract

Parental Cancer as a Risk Factor for Brain Tumors (Sweden)

Kari Hemminki1, Xinjun Li2, V. Peter Collins3

1Department of Biosciences, Novum, Karolinska Institute, 141 57 Huddinge, Sweden; Ph: 46-8-6089243; fax: 46-8-6081 501; e-mail: ; (Author for correspondence)kari.hemminki@cnt.ki.se; 2Department of Biosciences, Novum, Karolinska Institute, 141 57 Huddinge, Sweden; 3Department of Pathology, Division of Molecular Histopathology, University of Cambridge CB2 2QQ, UK

Objective. We used the nationwide Swedish Family-Cancer Database to analyze the risk for adult (1561 years) brain tumors in offspring through parental cancer probands. 
Additionally, cancer risks were assessed among siblings of brain tumor probands. 

Methods. In offspring and parents, respectively, 5425 and 20,938 cases of brain tumors were diagnosed between the years 1958 and 1996. 
Groups of offspring were compared by calculating standardized incidence ratios (SIRs) for brain tumors

Results. Of brain tumor patients, 2.1% had a parent with nervous system cancer; SIRs were 1.7, 2.4, and 2.5 for all brain tumors, astrocytomas, and meningiomas, respectively. 
Parental endometrial cancer and melanoma were associated with offspring astrocytoma, and parental breast and thyroid cancers with offspring ependymoma and neurinoma, respectively. 
SIR for sibling nervous system tumors from brain tumor probands was not increased overall but was 2.5 in those diagnosed at ages 1534 years. 

Conclusion. These data show a familial risk for brain tumors among adults.

Keywords: astrocytoma, ependymoma, familial risk, medulloblastoma, meningioma

Copyright © 2001 Kluwer Academic Publishers. All rights reserved

Source: http://www.kluweronline.com/article.asp?PIPS=318454


 

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