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Parental
Cancer as a Risk Factor for Brain Tumors (Sweden)
Kari
Hemminki1,
Xinjun Li2,
V. Peter Collins3
1Department
of Biosciences, Novum, Karolinska Institute, 141 57 Huddinge, Sweden; Ph:
46-8-6089243; fax: 46-8-6081 501; e-mail: ; (Author for correspondence)kari.hemminki@cnt.ki.se;
2Department
of Biosciences, Novum, Karolinska Institute, 141 57 Huddinge, Sweden; 3Department
of Pathology, Division of Molecular Histopathology, University of Cambridge CB2
2QQ, UK
Objective.
We used the nationwide
Swedish Family-Cancer Database to analyze the risk for adult (15–61
years) brain tumors
in offspring through parental cancer probands.
Additionally, cancer risks were assessed among siblings of brain
tumor
probands.
Methods.
In offspring and parents, respectively, 5425 and 20,938 cases of brain
tumors were
diagnosed between the years 1958 and 1996.
Groups of offspring were compared by calculating standardized incidence ratios
(SIRs) for brain tumors.
Results. Of brain tumor
patients, 2.1% had a parent with nervous system cancer; SIRs were 1.7, 2.4, and
2.5 for all brain
tumors,
astrocytomas, and meningiomas, respectively.
Parental endometrial cancer and melanoma were associated with offspring
astrocytoma, and parental breast and thyroid cancers with offspring ependymoma
and neurinoma, respectively.
SIR for sibling nervous system tumors from brain
tumor probands
was not increased overall but was 2.5 in those diagnosed at ages 15–34
years.
Conclusion. These data show a familial risk for brain
tumors among
adults.
Keywords:
astrocytoma, ependymoma, familial risk, medulloblastoma, meningioma
Copyright
© 2001 Kluwer
Academic Publishers. All
rights reserved
Source: http://www.kluweronline.com/article.asp?PIPS=318454
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