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Radiosurgery-induced
brain tumor. Case report
Kaido T, Hoshida T, Uranishi R, Akita N, Kotani A, Nishi N, Sakaki T
Department of Neurosurgery, Nara Medical University,
Kashihara, Japan
The authors describe a case of glioblastoma multiforme (GBM) associated
with previous gamma knife radiosurgery for a cerebral arteriovenous malformation
(AVM).
A 14-year-old boy had undergone radiosurgery for an AVM, which was performed
using a 201-source 60Co gamma knife system at another institution.
The maximum and margin radiation doses used in the procedure were 40 and 20 Gy,
respectively.
One year after radiosurgery, the patient noticed onset of mild left hemiparesis
due to radiation necrosis.
Six and one-half years after radiosurgery, at the age of 20 years, the patient
experienced an attack of generalized tonic-clonic seizure.
Magnetic resonance (MR) imaging revealed the existence of a brain tumor in the
right parietal lobe.
The patient underwent an operation and the histological diagnosis of the lesion
was GBM.
Ten months following the operation, that is, 99 months postradiosurgery, this
patient died.
To the best of the authors' knowledge, this is the first reported case of a
neoplasm induced by radiosurgery for an AVM and the second case in which it
occurred following radiosurgery for intracranial disease.
PMID: 11596968 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11596968&dopt=Abstract |
