|
|
OLIG2
as a specific marker of oligodendroglial tumour cells
Marie
Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J,
Zalc B, Hoang-Xuan K
OLIG2 is a recently identified transcription factor involved in the
specification of cells in the oligodendroglial lineage.
We
investigated the expression of OLIG2 by in-situ hybridisation in 21
brain tumours: nine grade II and III oligodendrogliomas, three grade
II oligoastrocytomas, and nine non-oligodendroglial tumours (four
grade IV astrocytomas, two meningiomas, a dysembryoplastic
neuroepithelial tumour, and two metastases).
OLIG2-positive
cells corresponding to neoplastic oligodendrocytes were present in all
oligodendrogliomas and oligoastrocytomas.
By
contrast, OLIG2 expression was not detected in the
non-oligodendroglial tumours.
Thus,
oligodendroglioma probably arise from oligodendrocyte precursor
cells.
OLIG2
should prove a useful marker for the diagnosis of oligodendroglial
tumours.
PMID: 11498220 [PubMed - indexed for MEDLINE]
|
