|
|
Primary
brain tumors following traumatic brain injury – a population-based cohort
study in Sweden
Catharina
Nygren1,+,
Johanna Adami2,
Weimin Ye2,
Rino Bellocco2,
Jean-Luc af Geijerstam3,
Jörgen
Borg1,
Olof Nyrén2
1Department
of Rehabilitation Medicine, Karolinska Institute, Danderyd Hospital, SE-182 88,
Stockholm, Sweden; Ph.: 46-8655 5484; Fax: 46-86226555; +catharina.nygren@mbox304.swipnet.se;
2Department
of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; 3Swedish
Council of Technology Assessment in Health Care, Stockholm, Sweden.
Objectives.
The aim of this study was to explore the association between traumatic brain
injury and brain tumor
development.
Methods.
A cohort of patients hospitalized for traumatic brain injury during 1965–1994
was compiled using the Swedish Inpatient Register.
Complete follow-up through 1995 was attained through record linkage with the
Swedish Cancer Register, the Cause of Death Register, and the Emigration
Register.
Standardized incidence ratios (SIRs), defined as the ratios of the observed to
the expected numbers of brain tumors,
were used as the measure of relative risk.
The expected number of brain tumors
was calculated by multiplying the observed person-time by age-, gender- and
calendar year-specific incidence-rates derived from the general Swedish
population.
Results.
The cohort included
311,006 patients contributing 3,225,317 person-years.
A total of 281 cases of brain tumors
were diagnosed during follow-up.
No associations were found between traumatic brain injury and the risk of
primary brain tumors,
neither overall (SIR: 1.0; 95% confidence interval (CI): 0.9–1.2),
nor in analyses broken down by main groups of brain
tumors. Stratified analyses according to
age at entry into the cohort, year of follow-up, and severity of the brain
injury all showed essentially the same null results.
Conclusion.
No association between traumatic head injury and primary brain
tumors has been found.
Keywords:
brain
tumor, epidemiology, risk factor,
traumatic brain injury
Copyright
© 2001 Kluwer
Academic Publishers. All
rights reserved
Source: http://www.kluweronline.com/article.asp?PIPS=353499
|
