brain tumors following traumatic brain injury – a population-based cohort
study in Sweden
Jean-Luc af Geijerstam3,
of Rehabilitation Medicine, Karolinska Institute, Danderyd Hospital, SE-182 88,
Stockholm, Sweden; Ph.: 46-8655 5484; Fax: 46-86226555; +firstname.lastname@example.org;
of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden; 3Swedish
Council of Technology Assessment in Health Care, Stockholm, Sweden.
The aim of this study was to explore the association between traumatic brain
injury and brain tumor
A cohort of patients hospitalized for traumatic brain injury during 1965–1994
was compiled using the Swedish Inpatient Register.
Complete follow-up through 1995 was attained through record linkage with the
Swedish Cancer Register, the Cause of Death Register, and the Emigration
Standardized incidence ratios (SIRs), defined as the ratios of the observed to
the expected numbers of brain tumors,
were used as the measure of relative risk.
The expected number of brain tumors
was calculated by multiplying the observed person-time by age-, gender- and
calendar year-specific incidence-rates derived from the general Swedish
The cohort included
311,006 patients contributing 3,225,317 person-years.
A total of 281 cases of brain tumors
were diagnosed during follow-up.
No associations were found between traumatic brain injury and the risk of
primary brain tumors,
neither overall (SIR: 1.0; 95% confidence interval (CI): 0.9–1.2),
nor in analyses broken down by main groups of brain
tumors. Stratified analyses according to
age at entry into the cohort, year of follow-up, and severity of the brain
injury all showed essentially the same null results.
No association between traumatic head injury and primary brain
tumors has been found.
tumor, epidemiology, risk factor,
traumatic brain injury
© 2001 Kluwer
Academic Publishers. All