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The
benefits and hazards of antioxidants: controlling apoptosis and other protective
mechanisms in cancer patients and the human population
Salganik
RI
Department
of Nutrition, School of Public Health, University of North Carolina, Chapel Hill
27599, USA. rsalganik@unc.edu
Cellular
oxidants, called reactive oxygen species (ROS), are constantly produced in
animal and human cells.
Excessive ROS can induce oxidative damage in cell constituents and promote a
number of degenerative diseases and aging. Cellular antioxidants protect against
the damaging effects of ROS.
However, in moderate concentrations, ROS are necessary for a number of
protective reactions.
Thus, ROS are essential mediators of antimicrobial phagocytosis, detoxification
reactions carried out by the cytochrome P-450 complex, and apoptosis which
eliminates cancerous and other life-threatening cells.
Excessive antioxidants could dangerously interfere with these protective
functions, while temporary depletion of antioxidants can enhance anti-cancer
effects of apoptosis.
Experimental data are presented supporting these notions.
The human population is heterogeneous regarding ROS levels.
Intake of exogenous antioxidants (vitamins E, C, beta-carotene and others) could
protect against cancer and other degenerative diseases in people with innate or
acquired high levels of ROS.
However, abundant antioxidants might suppress these protective functions,
particularly in people with a low innate baseline level of ROS.
Screening human populations for ROS levels could help identify groups with a
high level of ROS that are at a risk of developing cancer and other degenerative
diseases.
It also could identify groups with a low level of ROS that are at a risk of
down-regulating ROS-dependent anti-cancer and other protective reactions.
Screening populations could provide a scientifically grounded application of
antioxidant supplements, which could significantly contribute to the nation's
health.
PMID:
11603657 [PubMed - indexed for MEDLINE]
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