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Polyunsaturated
fatty acids, melatonin, and cancer prevention
Sauer LA,
Dauchy RT, Blask DE
Bassett
Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, NY 13326,
USA.
lensauer@juno.com
Many
nutritional, hormonal, and environmental factors affect carcinogenesis and
growth of established tumors in rodents.
In some cases, these factors may either enhance or attenuate the neoplastic
process.
Recent experiments performed in our laboratory using tissue-isolated rat
hepatoma 7288CTC in vivo or during perfusion in situ have demonstrated new
interactions among four of these factors.
Two agents, dietary linoleic acid (C18:2n6) and "light at night,"
enhanced tumor growth, and two others, melatonin and n3 fatty acids, attenuated
growth.
Linoleic acid stimulated tumor growth because it is converted by hepatoma
7288CTC to the mitogen, 13-hydroxyoctadecadienoic acid (13-HODE).
Melatonin, the neurohormone synthesized and secreted at night by the pineal
gland, and dietary n3 fatty acids are potent antitumor agents.
Both inhibited tumor linoleic acid uptake and 13-HODE formation.
Artificial light, specifically "light at night," increased tumor
growth because it suppressed melatonin synthesis and enhanced 13-HODE formation.
Melatonin and n3 fatty acids acted via similar or identical G(i) protein-coupled
signal transduction pathways, except that melatonin receptors and putative n3
fatty acid receptors were used.
The results link the four factors in a common mechanism and provide new insights
into the roles of dietary n6 and n3 polyunsaturated fatty acid intake,
"light at night," and melatonin in cancer prevention in humans.
PMID:
11377374 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11377374&dopt=Abstract
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