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Biological
mechanisms of glioma invasion and potential therapeutic targets
Tysnes BB,
Mahesparan R
Department
of Anatomy and Cell Biology, University of Bergen, Norway. berit.tysnes@pki.uib.no
The
current understanding of glioma biology reveals targets for anti-invasive
therapy which include manipulations of extracellular matrix and receptors,
growth factors and cytokines, proteases, cytoskeletal components, oncogenes and
tumor suppressor genes.
A better understanding of the complex regulation and the signalling molecules
involved in glioma invasion is still needed in order to design new and effective
treatment modalities towards invasive tumor cells.
Representative and valid in vitro experimental systems and animal models of
gliomas are necessary for the characterization of the invasive phenotype and
further development of anti-invasive therapy.
In the future, it will probably be important to move from comparative genomic
modelling through protein characterization based on advanced proteomic
techniques to analyse tissue samples, where the aim for gliomas should be to
compare invaded and non-invaded tissue.
This will hopefully render promising new therapeutic targets for gliomas.
PMID:
11716066 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11716066&dopt=Abstract
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