|
|
New
approach to tumor therapy for inoperable areas of the brain: chronic
intraparenchymal drug delivery
Carson BS Sr, Wu Q, Tyler B, Sukay L, Raychaudhuri R, DiMeco F,
Clatterbuck RE, Olivi A, Guarnieri M
Johns Hopkins Neurological Surgery and Hunterian Brain
Tumor Laboratories, Baltimore, MD 21287-8811, USA
Because the brainstem has little functional redundancy, diffuse lesions
have been regarded as inoperable.
To determine whether local drug therapy can prolong survival in a rodent model
of a tumor in such eloquent tissue, lethal doses of F98 and 9L tumor cells were
injected into the brainstems of Fischer 344 rats.
Five days after inoculations, 0.5 mg/ml solutions of carboplatin were infused at
1 microl/h for 7 days.
Compared to control groups that survived 13-17 days with F98 tumors and 22-23
days with 9L tumors, animals locally infused with 0.1 mg of carboplatin survived
27-30 days (Prob > Chi Sq = 0.0003), and 32 days (Prob > Chi Sq = 0.01),
respectively.
Measurements of tissue platinum levels at autopsy suggested that infusions
distributed pharmacologically relevant levels of carboplatin through a volume of
tissue at least 0.5 cm in diameter.
The results suggest that chronic low-flow infusions provide a promising approach
to therapy for CNS lesions in tissues considered to be inoperable.
PMID: 12635662 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12635662&dopt=Abstract
|
