|
|
Childhood
solid tumours in relation to infections in the community in Cumbria
during pregnancy and around the time of birth
Dickinson HO, Nyari TA, Parker L
North of England Children's Cancer Research Unit,
Department of Child Health, University of Newcastle, Royal Victoria
Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK
In a retrospective cohort study of all 99 976 live births in Cumbria,
1975-1992, we investigated whether higher levels of community
infections during the mother's pregnancy and in early life were risk
factors for solid tumours (brain/spinal and other tumours), diagnosed
1975-1993 under age 15 years.
Logistic regression was used to relate risk to incidence of community
infections in three prenatal and two postnatal quarters.
There was an increased risk of brain/spinal tumours among
children exposed around or soon after birth to higher levels of
community infections, in particular measles (OR for trend=2.1, 95%CI :
1.3-3.6, P=0.008) and influenza (OR for exposure=3.3, 95%CI : 1.5-7.4,
P=0.005).
There was some evidence of an association between exposure to
infections around and soon after birth and risk of other tumours, but
this may have been a chance finding.
The findings are consistent with other recent epidemiological studies
suggesting brain tumours may be associated with perinatal exposure to
infections.
PMID:
12232758 [PubMed - indexed for MEDLINE]
Source:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12232758&dopt=Abstract
|
