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The Use of Interleukin 12-secreting Neural Stem Cells for the Treatment of
Intracranial Glioma
Moneeb Ehtesham, Peter Kabos, Andrea
Kabosova, Toomas Neuman, Keith L. Black and John
S. Yu
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical
Center, Los Angeles, California 90048.
Correspondence should be addressed to J.S.Y. , at Maxine Dunitz
Neurosurgical Institute, Suite 800E, 8631 West 3rd Street, Los
Angeles, CA 90048. Phone: (310) 423-0845; Fax: (310) 423-0810; E-mail:
yuj@cshs.org.
Neural stem cells (NSCs) are capable of tracking migrating glioma cells.
To exploit this tropism to generate an antitumor T-cell response,
particularly against disseminating tumor pockets, we inoculated
intracranial glioma-bearing mice with interleukin 12 (IL-12)
producing NSCs.
Intratumoral therapy with IL-12-secreting NSCs
prolonged survival compared to treatment with nonsecretory NSCs or
saline.
NSCs demonstrated strong tropism for disseminating glioma,
and IL-12-secreting NSC therapy was associated with enhanced T-cell
infiltration in tumor microsatellites and long-term antitumor
immunity.
These results indicate that the use of tumor tracking NSCs
represents a potent new therapeutic modality for glioma.
© 2002 American Association for Cancer Research
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