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Gliomas
presenting after age 10 in individuals with neurofibromatosis type 1 (NF1)
Gutmann DH, Rasmussen SA,
Wolkenstein P, MacCollin MM, Guha A, Inskip PD, North KN, Poyhonen M, Birch PH,
Friedman JM
Department of Neurology, Washington University School of
Medicine, St. Louis, MO 63110, USA. gutmannd@neuro.wustl.edu
Children with neurofibromatosis 1 (NF1) often develop low-grade gliomas,
but brain tumors are infrequently encountered in adults with NF1.
The authors present evidence from two clinical series, one including patients
known to have NF1 and another focusing on adults with new onset brain tumors,
that suggests an association between NF1 and symptomatic gliomas in older
individuals.
They also summarize the clinical data on 17 adolescents or adults with NF1 and
symptomatic gliomas.
The findings suggest that individuals with NF1 are at increased risk of
developing gliomas throughout their lives.
PMID: 12221173, UI: 22209810
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12221173
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