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Treatment
of ocular lymphoma
Adilia
Hormigo, Lauren E Abrey, Lisa M DeAngelis
New
York-Presbyterian Hospital, New York, NY; Memorial Sloan-Kettering Cancer
Center, New York, NY
Isolated
ocular lymphoma is increasing in frequency and represents a difficult extranodal
site to treat.
Furthermore 80% of patients eventually develop cerebral involvement.
We report the results of initial treatment for ocular lymphoma in nineteen
patients.
Ten women and 9 men with a median age of 64 (range, 31 to 82 years) presented
with unilateral symptoms in 11 and bilateral symptoms in 8.
Ocular symptoms were present a median of 12 months (range 4 to 72 months) before
definitive diagnosis.
Diagnosis was made by vitrectomy in 10 and by brain biopsy in 9 patients whose
ocular disease was appreciated only at central nervous system (CNS) progression.
Eleven patients received steroids prior to definitive treatment for ocular
lymphoma, 4 had partial, transient improvement, 4 had no improvement and 3 had
no documented response.
Seven patients had definitive treatment of isolated ocular lymphoma.
Three patients received chemotherapy, 2 received chemotherapy plus RT and 2
ocular RT only.
These patients developed isolated CNS progression a median of 37.5 months (range
17 to 84) and one developed an ocular recurrence 23 months after onset of ocular
symptoms.
Their median survival was 41 months (range 20 to 133) from initial diagnosis of
ocular lymphoma, but only 23 months (12 to 118 months) after CNS progression.
Twelve patients had concurrent CNS disease (11 brain and one leptomeningeal)
when their ocular lymphoma was diagnosed.
Four were treated with chemotherapy, 5 received chemotherapy plus RT and 3 RT
only.
Ten patients had ocular response and 2 did not; all those with an ocular
response had a simultaneous response of their CNS disease.
Ocular lymphoma responds to a variety of therapies but treatment with
chemotherapy and/or RT failed to prevent CNS progression.
© Copyright 2002
American
Society of Clinical Oncology
Source:
http://www.asco.org/ac/1,1003,_12-002324-00_18-002002-00_19-00297-00_29-00A-00_42-00ONeill-00_43-00-00_44-00-00_45-00
Author-00_46-00Title-00_47-00Title-00_48-00and-00_49-00and,00.asp?cat=CNS+Tumors&parent=CENTRAL+NERVOUS+SYSTEM+TUMORS
&returnpid=2323
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