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Induction
of Tumor Necrosis Factor Production and Antitumor Effect by Cabbage Extract
Wataru
Komatsu, Yutaka Miura, Kazumi Yagasaki
The
effect of cabbage extract on the production of tumor necrosis factor and its
implication in the antitumor effect were examined in vitro and in vivo.
Cabbage extract stimulated the production of tumor necrosis factor by rat spleen
cells and showed cytotoxic activity in a rat ascites hepatoma cell line (AH109A)
when hepatoma cells were cultured with cabbage-stimulated spleen cells.
When the extract was administered orally to AH109A-bearing rats in combination
with lipopolysaccharide injection, the hepatoma weights were reduced to one-half
of the vehicle control.
The cytotoxic activity of tumor-infiltrating macrophages was induced by
simultaneous treatment with cabbage extract and lipopolysaccharide.
These results indicate that cabbage extract contains macrophage-stimulating
component(s) and can implement the antitumor effect by stimulating the
cytotoxicity of tumor-infiltrating macrophages.
©
Lawrence Erlbaum Associates, Inc.
Source:
http://angelina.ingentaselect.com/vl=110498/cl=46/nw=1/rpsv/catchword/erlbaum/01635581/v43n1/s10/p82
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