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Highly
unsaturated fatty acid induced tumour regression in glioma pharmacodynamics and
bioavailability of gamma linolenic acid in an implantation glioma model: effects
on tumour biomass, apoptosis and neuronal tissue histology
Leaver HA, Wharton SB, Bell HS, Leaver-Yap IM, Whittle IR
Department of Clinical Neurosciences, University of Edinburgh, UK.
pengl@netcomuk.co.uk
Highly unsaturated fatty acids (HUFAs) are naturally occurring anti-tumour
agents.
HUFAs act as intracellular signalling molecules in cell proliferation and
death.
In human glioma, HUFAs may stimulate tumour regression and apoptosis.
An implantation glioma model, using the C6 glioma cell line, was used to
investigate the bioactivity of locally infused n-6 HUFA gamma linolenic acid
(GLA).
Rat brains (15 normal and 37 C6 tumour bearing) were infused with vehicle or GLA
200 microM-2 mM.
The most active local concentration of GLA for anti-tumour activity was 2 mM,
infused at 1 microl/h over 7 days.
Tumour regression, increased apoptosis and decreased proliferation were observed
in tumours of rats infused with this concentration of GLA.
Little effect on normal neuronal tissue was detected.
The intraparenchymal route was an effective method of GLA administration in the
treatment of glioma.
These studies provide further insights into the potential role of HUFAs as
anti-glioma agents.
PMID: 12445487 [PubMed - in process]
Source: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12445487&dopt=Abstract
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